“GLA group”: These proteins all contain an essential N-terminal glutamic acid rich GLA domain[16,17]that is used in anchoring the protein to thephospholipid bilayer. In theabsenceof sufficient vitamin K or in the presence of vitamin K reductase inhibitors, the GLA-containing factors are rende...
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In recent years, proteinacetylationhas emerged as a fundamentalPTM, rivalling phosphorylation in its relevance to the regulation ofbiological processes[165]. Proteins may become acetylated either at the α-amino group of the protein N-terminus or the ε-amino group of Lys residues. The binding of...
Changes in RNA localization upon eIF3d siRNA are relative to the RNA localization in the scrambled siRNA condition. Error bars represent standard deviation (n = 5 independent cytosol and membrane RNA extractions per condition). **P = 0.0079 (two-tailed Mann–Whitney U test). g, ...
Protein–DNA interactions are key to the functionality and stability of the genome. Identification and mapping of protein–DNA interaction interfaces and sites is crucial for understanding DNA-dependent processes. Here, we present a workflow that allows
( 2003 ) Protein C and protein S assessment in hospital laboratories: which strategy and what role for DNA sequencing? Blood Coagulation and Fibrinolysis , 14 , 531 – 538 .Labrouche S,Reboul MP,Guerin V,Vergnes C,Freyburger G. Protein C and protein S assessment in hospital laboratories: ...
Increasing numbers of protein interactions have been identified in high-throughput experiments, but only a small proportion have solved structures. Recently, sequence coevolution-based approaches have led to a breakthrough in predicting monomer protein s
In contrast, when trained on the RPI369 dataset, the SVM classifiers out-performed the RF classifiers (Table 3). Overall, the SVM classifier correctly predicted 1,402 (83%) and the RF classifier correctly predicted 1,115 (66%) of the interactions. Among the 1,402 interactions correctly pred...
Also disclosed are methods for utilizing HUTAPL polypeptides and polynucleotides in diagnostic assays.doi:CA2404495 A1Silke BrandtChrista BurgerEP
Sterol carrier protein-2/3-oxoacyl-CoA thiolase (SCPx) gene has been suggested to be involved in absorption and transport of cholesterol. Cholesterol is a membrane component and is a precursor of ecdysteroids, but cannot be synthesized de novo in insects