The Protein Homology NetworkDuccio, Medini
Exploiting sequence–structure–function relationships in biotechnology requires improved methods for aligning proteins that have low sequence similarity to previously annotated proteins. We develop two deep learning methods to address this gap, TM-Vec a
至此,SpA的E-D-A-B-CX序列结构才算完成。从进化角度,SpA的5个IgG结合结构域氨基酸序列高度同源,并且存在同源梯度 (homology gradient) ,即相邻的两个区域,同源性更高(如图1)。说明原始祖先基因,在进化过程中被复制多次,并存在点突变,体现出stepwise multiple DNA dupl...
Remote protein homology detection suite. Contribute to soedinglab/hh-suite development by creating an account on GitHub.
Protein homology detection by HMM–HMM comparison. Bioinformatics 21, 951–960 (2005). Article Google Scholar Xu, J., McPartlon, M. & Li, J. Improved protein structure prediction by deep learning irrespective of co-evolution information. Nat. Mach. Intell. 3, 601–609 (2021). Article ...
网络蛋白质同源网络 网络释义 1. 蛋白质同源网络 蛋白质同源网络(Protein Homology Network),感谢Alex Adai:细胞和分子生物学院 - 德州大学数据和系统的互联性增加产 … www.infoq.com|基于25个网页
Saigo H, Vert J, Ueda N, Akutsu T: Protein homology detection using string alignment kernels. Bioinformatics 2004, 20: 1682–1689. Article CAS PubMed Google Scholar Pearson WR, Lipman DL: Improved tools for biological sequence comparison. PNAS 1988, 85: 2444–2448. Article PubMed Central ...
Hemmingsen, LarsExplorer, ProteinSwisspdbviewer, DownloadSwisspdbviewer, LaunchSequence, Load Raw
Ma K, Inglis JD, Sharkey A, Bickmore WA, Hill RE, Prosser EJ, Speed RM, Thomson EJ, Jobling M, Taylor K, et al: A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis. Cell. 1993, 75 (7): 1287-1295....
MAPK signalling involves a three-tiered phosphorylation cascade comprising the effector MAPK, a MAPK kinase (MAPKK), and a MAPKK kinase (MAPKKK). The Ser/Thr extracellular signal-regulated kinases 1 and 2 (ERK1/2, 83% homology) are well-known members of the MAPK family (MAPK3 and MAPK1,...