日前，由天鹜科技创始人&首席科学家洪亮教授团队提出的ProtSSN几何感知大模型系列，在哈佛医学院ProteinGym-Substitution榜单中崭露头角，夺得非检索方法排名第一的桂冠，并在总榜TOP10的排名中占据了5个席位。此外，这一系列大模型在多个关键领域均展现出卓越的性能：对真核蛋白的预测能力位居榜单第一，对原核蛋白的...
我们在蛋白质突变数据集(ProteinGym)上和真实人类临床疾病数据集(ClinVar)上测试了SaProt的zero-shot能力,结果如下: Zero-shot实验结果 我们的模型在两个数据集上都超越了以往的所有结构和序列模型,证明了我们模型在zero-shot预测突变上有优异能力。 监督微调测试 我们涵盖了各种下游任务来测试模型表现,结果如下: 下...
ProteinGym OverviewProteinGym is an extensive set of Deep Mutational Scanning (DMS) assays and annotated human clinical variants curated to enable thorough comparisons of various mutation effect predictors in different regimes. Both the DMS assays and clinical variants are divided into 1) a ...
ProteinGym: large-scale benchmarks for protein fitness prediction and design. In Advances in Neural Information Processing Systems (NeurIPS) Vol. 36 (2023). Russ, W. P. et al. An evolution-based model for designing chorismate mutase enzymes. Science 369, 440–445 (2020). MathSciNet CAS ...
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Assessed on the ProteinGym (Notin et al. 2023) benchmark, VespaG matches state-of-the-art methods while being several orders of magnitude faster, predicting the entire single-site mutational landscape for a human proteome in under a half hour on a consumer-grade laptop....
Fourteen grams of protein is provided by four slices of chicken or turkey. It is stated that hard-boiled eggs are most convenient and provide 19 grams protein. According to a study published in the "Journal of the American College of Nutri...
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