Cancer is a multifactorial disease resulting from somatic mutation and selection of a cell population that evades normal constraints on proliferation, invades tissues, and spreads to other organs. Changes in cellular glycosylation confer adaptive advantages to cells during tumor progression. Indeed, ...
There are two major types of protein glycosylation in mammalian cells, namelyN-linked andO-linked. Both types often coexist in the same protein. The synthesis ofN-glycans is initiated in the ER by transfer of a preformed lipid (dolichopyrophosphate)-linked oligosaccharide precursor containing three ...
NAD Precursors, Mitochondria Targeting Compounds and ADP-Ribosylation Inhibitors in Treatment of Inflammatory Diseases and Cancer. Curr Med Chem. 2021;288453–79. Article CAS PubMed Google Scholar Moremen KW, Tiemeyer M, Nairn AV. Vertebrate protein glycosylation: diversity, synthesis and function. ...
Changes in glycosylation on the cell surface disrupt the interactions between glycans and lectins, which helps cancer cells escape from the immune surveillance (Macauley, Crocker, & Paulson, 2014; Rabinovich & Toscano, 2009). Therefore, characteristic alterations of glycosylation in many diseases can ...
with great advances in proteomic techniques, several other PTMs, such as acetylation, glycosylation, sumoylation, methylation, ubiquitination, citrullination, and palmitoylation have been confirmed in breast cancer. Nevertheless, the mechanisms, effects, and inhibitors of these unconventional PTMs (particul...
with great advances in proteomic techniques, several other PTMs, such as acetylation, glycosylation, sumoylation, methylation, ubiquitination, citrullination, and palmitoylation have been confirmed in breast cancer. Nevertheless, the mechanisms, effects, and inhibitors of these unconventional PTMs (particul...
In this present review, we discuss the unfolding account of these APP family members’ roles in cancer progression and metastasis. INTRODUCTION Amyloid precursor protein (APP) is an evolutionarily conserved protein with two homologues in mammals: amyloid precursor-like protein 1 (APLP1) and amyloid ...
However, glycosylation of proteins is also involved in disease development. Pathologies ranging from inflammatory conditions, to rheumatoid arthritis, Alzheimer's and cancer, to name a few, were associated with aberrant glycosylation patterns. For instance, in cancer cells, a wrong glycosylation might ...
Site-selective modifications of arginine residues in human hemoglobin induced by methylglyoxal. Biochemistry 45, 15654–15660 (2006). Article CAS PubMed Google Scholar Shapiro, R., McManus, M. J., Zalut, C. & Bunn, H. F. Sites of nonenzymatic glycosylation of human hemoglobin A. J. Biol...
as well as how changes in glycosylation can affect cell function. In addition, our understanding of the role of protein glycosylation in disease processes is growing, particularly in the context of immune system function, infectious diseases, neurodegeneration and cancer. Several decades ago, cell sur...