To determine whether the identified sex-specific causal proteins show sex-specific genetic risk, we asked whether the genetic interaction with sex in the corresponding GWAS was nominally significant for the considered trait for the sites that were most significantly associated with the trait at the lo...
Meaning The recommended dietary allowance for protein is sufficient to maintain lean body mass; protein intake exceeding the recommended dietary allowance does not increase lean body mass in functionally limited older men who are eating less than the recommended dietary allowance. Abstract Importance The...
In recent years, some PPIs modulators have entered clinical studies, some of which been approved for marketing, indicating that the modulators targeting PPIs have broad prospects. Here, we summarize the recent advances in PPIs modulators, including small molecules, peptides, and antibodies, hoping ...
Fig. 1. A–H: Bland–Altman plots of mean differences and limits of agreement between current or corrected bodyweight and FFM, stratified for BMI categories for men and female separately. In the participants with severe obesity, a notable underestimation of protein requirements in 26% is found,...
PPIs are pivotal regulatory events in biological systems, providing the structural and functional basis for cellular processes, while abnormal PPIs have been extensively implicated in many human diseases5, 6, 7. For example, mixed-lineage leukemia (MLL) fusion proteins directly interact with menin ...
Therefore, developing small molecule inhibitors to directly disrupt the MLL-menin interaction is a potential strategy for leukemia treatment [100, 101]. Furthermore, while many cancers are driven by aberrant kinase activity, it is thought that targeting the PPIs that regulate the activity of a ...
Moreover, each of these four resources has been curated by expert biologists to ensure quality. For clarity, in the description of these resources, we refer to the sets of proteins as "groups" or "families" or "clusters," and the name given to the set as the "class." The section ...
Dyslipidemia is a major risk factor for cardiovascular disease, and diabetes impacts the lipid metabolism through multiple pathways. In addition to the standard lipid measurements, apolipoprotein concentrations provide added awareness of the burden of ci
Whole-Body Protein Turnover in Preterm Appropriate for Gestational Age and Small for Gestational Age Infants: Comparison of [ 15N]Glycine and [1-13C]Leucine Administered Simultaneously1 J. B. VAN GOUDOEVE R, E . J. SULKERS, D. HALLIDAY, H. J. DEGENHART, V. P. CARNIELLI, J. L. D...
Covalently engineered nanobody chimeras for targeted membrane protein degradation. J. Am. Chem. Soc. 143, 16377–16382 (2021). Article CAS PubMed Google Scholar Verdurmen, W. P. R., Mazlami, M. & Pluckthun, A. A quantitative comparison of cytosolic delivery via different protein uptake ...