Far‐red‐light‐induced changes include up‐regulation of alternative copies of multiple proteins of Photosystem II (PS II). This includes an alternative copy of the D1 protein, D1FR. Here, we show that D1FR introduced into Synechocystis sp. PCC 6803 (hereafter Synechocystis 6803) can be...
mScarlet3-H is a highly stable monomeric red fluorescent protein with exceptional resistance to photobleaching, heat and chemical denaturation. Its great stability enhances advanced microscopy techniques, enabling long-term, high-resolution imaging of cellular processes. ...
The advancement of far-red emitting variants of the green fluorescent protein (GFP) is crucially important for imaging live cells, tissues and organisms. Despite notable efforts, far-red marker proteins still need further optimization to match the perfor
The study indicates that the transport of LCFAs to the chain elongation complex at the ER-membrane is impaired, so that these shorter-chain fatty acids cannot be elongated to VLCFAs. There is some evidence to suggest that ACBD1 may also play a role in the synthesis of VLCFAs in mammals....
How widespread is the use of modified N-glycosylation as a response to environmental change in Archaea? How does modified N-glycosylation contribute to the ability of Archaea to adapt to environmental changes? Do Bacteria also modify protein glycosylation in response to changing surroundings? Does O...
An important function of the UPR is its function as a homeostatic stress response initiated by ER dysfunction. In addition, it is employed to adjust the physiology of cells under situations where ER function is not impaired [81]. For example, during the differentiation of B-cells to antibody-...
1γ dead-mutant co-expression failed this rescue [27,28]. Subsequent analyses showed an interaction between PP1γ and Tat, as well as their co-localization in the nucleus [27]. Tat possesses a consensus RVxF motif (35QVCF38) and the mutation of this PP1-binding SLiM impaired the PP1...
term potentiation [29]; greater locomotor activity and less anxiety-like behavior than wild-type littermates [30]; abnormal phase-shifting of the circadian clock in response to light [31]; impaired responses to painful stimuli [32]; and reduced insulin secre- tion in response to glucose [33...
The production of type I IFN and IFN-stimulated genes (ISGs) was impaired in ERAL1-deficient cells. Overexpression of ERAL1 promoted the induction of type I IFN by RNA virus infection. Mechanistically, RNA virus infection can trigger the translocation of ERAL1 from mitochondrial matrix to ...
Metabolic diseases often share common traits, including accumulation of unfolded proteins in the endoplasmic reticulum (ER). Upon ER stress, the unfolded protein response (UPR) is activated to limit cellular damage which weakens with age. Here, we show t