There are at least eight family members in humans (dysbindin-1A, -1B, -1C, -2A, -2B, -2C, -3A, and -3B). Dysbindin-1 is distinguished from other paralogs of the dysbindin family by the presence of a coiled coil domain important in interactions with other proteins. We focus on ...
The lamins are members of the intermediate filament (IF) family of proteins, which constitute a major component of the cytoskeleton. Lamins are the only nuclear IFs and are the ancestral founders of the IF protein superfamily. Lamins polymerize into fibers forming a complex protein meshwork in ...
Specificity of the isolated clones was first evaluated by phage-ELISA response towards the tandem PDZ domains of PSD-95, as compared to the other DLG family members (Fig. 2c). Most clones showed specificity for PSD-95, which was remarkable given the absence of negative selection. Performing ...
B-cell lymphoma-2 (BCL-2) family proteins regulate programmed cell death. Some members of the family (such as BCL-2 and BCL-XL) inhibit apoptosis, whereas others (such as BAX and BAK) promote cell death. BH3-only proteins are a distinct and structurally diverse class of proteins that sh...
Other members of the PDI family differ substantially in terms of the a/b-domains configurations and other important motifs (Fig.1A). Phylogenetic analysis that is based on sequence similarities of PDI reveals the existence of multiple subfamilies, markedly the AGR (TXNDC12, AGR2, AGR3), TMX...
to the text.1)A single fragment of a LytR-CpsA-Psr protein was detected in the δ-Proteobacterium Plesiocystis pacificastrain SIR-1.2)Except for theDehalococcoides, which are representing the phylum of theChloroflexiin this tree, all members of theChloroflexicontain LytR-CpsA-Psr family members...
In the case of GRK2 and GRK3, the RH domain has been shown to interact with GTP-liganded Gαq family members [23, 24]. A central catalytic domain with high similarity to other AGC protein kinases, such as PKA, PKB, and PKC, is shared by all GRKs, whereas a more variable carboxyl...
Chloride Intracellular Channel 4 (CLIC4) is one of seven members in the closely related CLIC protein family. CLIC4 is involved in multiple cellular processes including apoptosis, cellular differentiation, inflammation and endothelial tubulogenesis. Despite over a decade of research, no comprehensive in...
The Wiskott-Aldrich syndrome family of proteins (WASp) regulates the activation of the Arp2/3 complex through the verprolin-homology (V), cofilin-like (C), and acidic (A) (VCA) regions at their C terminus (5, 6, 7). This family consists of eight members: WASp, N-WASp, WAVE1–3,...
The I2C family from the wilt disease resistance locus I2 belongs to the nucleotide binding, leucine-rich repeat superfamily of plant resistance genes R: The I2C family from the wilt disease resistance locus I2 belongs to the nucleotide binding, leucine-rich repeat superfamily of plant resistance ...