In patients with chronic obstructive pulmonary disease, with active or past infections or who had heart failure, the elevated concentrations of CRP measured via the patch correlated well with the protein’s levels in serum. Wearable biosensors for the real-time sensitive analysis of inflammatory ...
We asked whether any of the genes with sex-biased expression identified here are also causal genes in 24 psychiatric, neurologic and brain morphologic traits found in our recently published study20. In that work, we identified brain proteins that are consistent with a causal role in those traits...
like prealbumin or albumin. An elevation in C-reactive protein indicates acute inflammatory response. As long as C-reactive protein is elevated, prealbumin and albumin are significantly depressed.5Since RBP is relatively unaffected by the acute inflammatory response, RBP appears to be a more reliable...
, indicating that elevated α-synuclein expression may foster disease in a specific cell type rather than at the tissue level. Through examination of more readily accessibleblood cells, individuals carryingSNCAtriplication or a greater number of Rep1 dinucleotide repeats were shown to have elevated ...
datasets of human clinical samples have identified that the expression of PDI members is elevated in pathophysiological states like cancer. Subsequent functional interrogations using structural, molecular, cellular, and animal models suggest that some PDI members support the survival, progression, and ...
Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction. J. Clin. Invest. 2020;140(8):4104–17. https://doi.org/10.1172/JCI122237. Article Google Scholar Hartz AMS, Bauer B, Soldner ELB, Wolf A, Boy S, Backhaus R, Mihaljevic I, Bogdahn U, Klüne...
Variation in the gene encoding dysbindin-1 (i.e., dystrobrevin-binding protein 1: DTNBP1) has frequently been associated with schizophrenia. Several studies have also found that dysbindin-1 gene and protein expression are altered in two affected brain ar
Elevated c-reactive protein levels in overweight and obese adults. JAMA, 1999; 282, 2131-5. doi: 10.1001/jama.282.22.2131 [15] Nevill AM, Stewart AD, Olds T, et al. Relationship between adiposity and body size reveals limitations of BMI. Am J Phys Anthropol, 2006; 129, 151-6. doi:...
Elevated levels of Secreted-Frizzled-Related-Protein 1 contribute to Alzheimer’s disease pathogenesisPilar Esteve, Javier Rueda-Carrasco, María Inés Mateo, María Jesús Martin-Bermejo, Jonathan Draffin, Guadalupe Pereyra, África Sandonís, Inmaculada Crespo, Inmaculada Moreno, Ester ...
Here, we quantified NfL in CSF and blood in R6/2 mice using the ultra-sensitive immunoassay, Single molecule array (Simoa)-based immunoassay technology15,16,17. We found that NfL was elevated in R6/2 mice in both fluids; its level was significantly associated with measures of clinical and ...