Domain structures appear repeatedly in the protein molecules, singly or in combination with other domains7. More than two-thirds of protein sequences are longer than an average domain length, a vast majority of which are multidomain proteins19. A study of protein structures in 749 genomes showed...
InterProScan: protein domains identifier InterProScan [E. M. Zdobnov and R. Apweiler (2001)Bioinformatics, 17, 847–848] is a tool that combines different protein signature recognition methods fro... E Quevillon,V Silventoinen,S Pillai,... - 《Nucleic Acids Research》 被引量: 3366发表:...
6. This possibility seems unlikely, however, given that all 6 variants are two-domain proteins whose N-terminal NGN domains are highly conserved23. Furthermore, Variants #3 and #5 have been shown by NMR previously25or here to assume two folds. The success of our method in the NusG superfa...
Protein phosphorylationhas become a central focus ofdrug discoveryas the result of the identification and validation of promising therapeutic targets such asprotein kinases, proteinphosphatases, andphosphoproteinbinding domains.1–24With respect to suchprotein phosphorylationtherapeutic targets, significant progres...
In fact, our groups have determined 1333 solution structures of human/mouse proteins (Table 1, mostly functional domains), by using the E. coli cell-free method for the preparation of uniformly labeled protein samples (Kigawa, Inoue, et al., 2008; Yokoyama, Terwilliger, Kuramitsu, Moras, &...
It has been well over thirty years since Wetlaufer formally introduced what he termed structural regions of a protein chain. Such regions were portions of the peptide sequence which assumed a compact structure [1]. In modern parlance, these units are known as domains. Protein domains are structu...
InterPare presents interfaces between protein domains identified by three methods. First, the interface is detected by calculating the geometric distance between subunits of multidomain proteins or protein complexes in the PDB [22, 27]. In the second approach, buried protein regions are identified by...
Deep-learning-based design of synthetic orthologs of SH3 signaling domains Xinran Lian, Nikša Praljak, Subu K. Subramanian, Sarah Wasinger, Rama Ranganathan, Andrew L. Ferguson Cell Systems (2024) 5.3 GAN-based Feedback GAN for DNA optimizes protein functions Gupta, Anvita, and James Zou...
We describe the Conserved Domain Search service (CD-Search), a web-based tool for the detection of structural and functional domains in protein sequences. CD-Search uses BLAST(R) heuristics to provide a fast, interactive service, and searches a comprehensive collection of domain models. Search ...
Characterizing protein function? Explore PROTBANK™ – GenScript’s integrated protein database containing information for >2 million proteins across 186 species. Learn more about a protein’s sequence, structure, functions, domains and more. And if you need recombinant protein for your experiments,...