Ren Wei-fu, Bian Qi. Research advances of protein N-glycosylation’s biological functions and analytical methods and its role in kidney disease[J]. Journal of Clinical Nephrology, 2021, 21(11): 935-941. DOI: 10.3969/j.issn.1671-2390.2021.11.009 ...
蛋白质和蛋白质组学2.Protein folding, misfolding and disease-revised.ppt,Ubiquitin is attached to a protein * Which E2s and E3s are involved in this cellular quality-control system and how they recognize misfolded proteins are still open questions. It is
death anddisease progression;glycansserve as specific therapeutic targets of cancers. In this context, we are reviewing the molecular mechanisms of the glycan-lectin regulatory network as an integral part of cell death machinery in cancer to target them for successful therapeutic andclinical approaches....
The peptide content was estimated by UV light spectral density at 280 nm using an extinction coefficient of 1.1 of 0.1% (g/l) solution, which was calculated based on the frequency of tryptophan and tyrosine in vertebrate proteins. Lectin enrichment and deglycosylation in H2O18 The digested ...
tuberculosis [159], while deglycosylation of Apa decreased its capacity to elicit cellular immune responses [160], [161]. In addition, PstS-1, which is also O-mannosylated, could induce the apoptosis of macrophages through the activation of TLR2, TNF-α and FasL, which subsequently destroys ...
Additionally, we uncover that the viral Hemagglutinin neuraminidase (HN) protein induces the deglycosylation and degradation of lysosome-associated membrane protein 1 (LAMP1) and LAMP2 dependent on its sialidase activity, which finally contributes to NDV-induced LMP and cellular ...
Protein deglycosylation can drastically affect the cellular uptake. Nanoscale 11, 10727–10737 (2019). Article CAS Google Scholar Corbo, C., Molinaro, R., Tabatabaei, M., Farokhzad, O. C. & Mahmoudi, M. Personalized protein corona on nanoparticles and its clinical implications. Biomater. ...
and common disease pathways. By employing highly discriminatory anti-PrP antibodies and conversion-tolerant PrP chimera, we here report that de novo PrP conversion and formation of fibril-like PrP aggregates are distinct in mechanistic and kinetic terms. De novo PrP conversion occurs within minutes ...
Section > Chapter Takahashi, M.; Tsujioka, Y.; Yamada, T.; Tsuboi, Y.; Okada, H.; Yamamoto, T.; Liposits, Z. Acta Neuropathologica 97(6): 635-641 1999 ISSN/ISBN:0001-6322 10378383 10.1007/s004010051040 010721686 Full-Text Article emailed within 0-6 h ...
Please note:An enzymatic deglycosylation is a commonly used experimental technique to verify whether a studied protein is glycosylated. Prior to WB, the protein sample is incubated with an enzyme that is able to remove parts or full glycan chains. WB ...