ARTICLES Normal Function of the Cystic Fibrosis Conductance Regulator Protein Can Be Associated with Homozygous ⌬F508 Mutation ISABELLE SERMET-GAUDELUS, BENOIT VALLÉE, ILSE URBIN, TANIA TOROSSI, RÉMI MARIANOVSKI, ANNE FAJAC, MARIE-NOËLLE FEUILLET, JEAN-LOUIS BRESSON, GÉRARD LENOIR, JEAN...
Similarly, with its high signal-to-noise ratio, synchrotron FTIR (S-FTIR) was also implemented to study the protein secondary structure in natural silk fibers37,51. However, due to the complex structural makeup of cylindrical spider silks and quasi-cylindrical silkworm silks, no direct ...
(left); the actual ratio is ∼5:1 (right). Conversely, the ratio of low cerebrospinal fluid (soluble) Aβ42levels to dementia is close to 1:1. Virtually no patient with Alzheimer’s disease has high Aβ42levels but most amyloid-positive individuals remain normal throughout their life...
(molecular mass of about 20 kDa) is synthesized mainly by the hepatocytes and secreted when bound to retinol in a molar ratio of 1:1 and to a 55 kDa homo-tetrameric protein, transthyretin (TTR). The association of RBP with TTR stabilizes the complex and increases the size of the RBP-...
Variation in the gene encoding dysbindin-1 (i.e., dystrobrevin-binding protein 1: DTNBP1) has frequently been associated with schizophrenia. Several studies have also found that dysbindin-1 gene and protein expression are altered in two affected brain ar
Markus CR, Olivier B, Panhuysen GE, Van der Gugten J, Alles MS, Tuiten A, Westenberg HG, Fekkes D, Koppeschaar HF, de Haan EE (2000) The bovine protein α-lactalbumin increases the plasma ratio of tryptophan to the other large neutral amino acids, and in vulnerable subjects raises brai...
The lamins are the major architectural proteins of the animal cell nucleus. Lamins line the inside of the nuclear membrane, where they provide a platform for the binding of proteins and chromatin and confer mechanical stability. They have been implicated
Accumulating evidence indicates that components of the systemic inflammatory response, such as C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR), have been associated with prognosis of various cancers. We aimed to elucidate whether CRP and NLR could serve as potential surrogate markers...
Firstly, there are only three inputs in our machine learning: the percentage of interface residues on loops of each of the two interacting proteins (factor of flexibility) and the ratio of the electrostatic potential at the binding interface to that of the whole protein pair (factor of ...
Data were tested for statistical significance via a two-sided bootstrap ratio test. ***P < 0.001; n.s., non-significant; LE, labeling efficiency. Source data Full size image Discussion In conclusion, we have developed a method to evaluate absolute labeling efficiency of binders, which is...