We found that Ankyrin repeats were the most frequently found among these viruses, followed by LRRs. These two types of repeats were found in all the families, while TPRs were mainly found in the Mimiviridae family, KELCH in Phycondaviridae and Poxviridae families, and RCC1 only in two ...
including viruses such as human cytomegalovirus (HCMV), the leading infectious cause of congenital disorders in the USA. Due to the large number of encoded genes
We then summed, for each immunized mouse, the titers of 50% neutralizing antibody against all pseudoviruses (pVNT50) for each group and found that the total pVNT50 in the Tri-Vac group surpassed those of the individual antigen groups (Fig. 2f). Two additional trivalent vaccines, with ...
Intrinsically disordered proteins, defying the traditional protein structure–function paradigm, are a challenge to study experimentally. Because a large part of our knowledge rests on computational predictions, it is crucial that their accuracy is high.
Animal proteins are considered to be complete, or high-quality, protein, because they have all of the essential amino acids that are needed by humans. Plant proteins are found in legumes, nuts, vegetables, seeds, some fruits and the products that are made from these foods. Plant proteins ...
capsid - the outer covering of protein surrounding the nucleic acid of a virus virion - (virology) a complete viral particle; nucleic acid and capsid (and a lipid envelope in some viruses) protein - any of a large group of nitrogenous organic compounds that are essential constituents of living...
It has been for more than 30 years, since the first discovery of NEDD8 in 1992. Figure2summarized the milestone discoveries in the neddylation field, covering from target identification, validation, drug discovery to clinical trials, and clinical approval of a neddylation inhibitor for treatment of...
Soluble forms of the IFN-alpha receptor, corresponding to truncated forms of the extracellular domain of the cell surface IFN-alpha receptor, have been found in human serum and in normal human urine. All known subtypes of IFN-alpha show the same antiviral antiparasitic, antiproliferative activities...
The bacterium Candidatus Liberibacter asiaticus (CLas) causes citrus Huanglongbing disease. Our understanding of the pathogenicity and biology of this microorganism remains limited because CLas has not yet been cultivated in artificial media. Its genome
(1) Tomato bushy stunt virus replication protein p33, also found in other tombus viruses. (2) A tumour suppressor p33 (ING1b). (3) Complement and kininogen binding protein gC1qR/p33 (gC1qR), distinct from calreticulin. (4) Eukaryotic translation initiation factor 3 subunit G (translation ...