具体来讲,纳米粒子由于具有较高的表面自由能,进入生物体内环境之后,环境蛋白质等物质会吸附与纳米颗粒的表面从而形成一层或多层的特殊结构,称为蛋白冠。这一动态过程,受蛋白质在纳米颗粒表面的连续吸附和平衡情况控制(对应的平衡常数),根据吸附强弱,分为类共价键的结合紧密的硬冠和类范德华力的结合较弱的软冠。 ...
Our results suggest that the formation of a whey protein corona around TiO2 nanoparticles may have beneficial effects on their behavior within the colon. This study provides valuable new insights into the potential impact of protein coronas on the gastrointestinal fate of inorganic nanoparticles. 展开 ...
Mechanistic Understanding of Protein Corona Formation around Nanoparticles: Old Puzzles and New Insights Although a wide variety of nanoparticles (NPs) have been engineered for use as disease markers or drug delivery agents, the number of nanomedicines in clin... K Nienhaus,GU Nienhaus - 《Small》...
Protein corona formation was proved by the size and zeta potential measurements, while the size increments of the BHb group were the most significant ones. We hypothesized that the hydrophilic protein might be dominated by the surface adsorption mode, where the proteins were cross-linked by the ...
具体来讲,纳米粒子由于具有较高的表面自由能,进入生物体内环境之后,环境蛋白质等物质会吸附与纳米颗粒的表面从而形成一层或多层的特殊结构,称为蛋白冠。这一动态过程,受蛋白质在纳米颗粒表面的连续吸附和平衡情况控制(对应的平衡常数),根据吸附强弱,分为类共价键的结合紧密的硬冠和类范德华力的结合较弱的软冠。 ...