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et al. Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2. Cell 183, 1367–1382 (2020). CAS PubMed PubMed Central Google Scholar Brouwer, P. J. M. et al. Two-component spike nanoparticle vaccine protects macaques from SARS-CoV-2 ...
we prepared sets of EATs and a corresponding enzyme (Fig.1c)27. Using such pairs can convert an input (a non-enzymatic target protein) into enzymatic activity (Fig.1a); thereby, a gelator can be decomposed to induce a macroscopic gel–sol transition. The EAT consists of the ligand of a...
Upon bait–prey interaction, a functional receptor is reconstituted and can be activated by a cytokine ligand (indicated by L at the extracellular component of the receptor). This ligand-binding leads to cross-phosphorylation of JAKs, which in turn phosphorylate the prey receptor-fragment, ...
Protein synthesisis a core component of cellular regulation and, as such, has profound effects at tissue, organ, and whole body levels.Protein synthesiscan be stimulated or inhibited in response to both endogenous and exogenous stimuli, allowing for adaptation and appropriate reactions to various stre...
Two examples of proteins present in the cell as different protein species are the well-known proteins angiotensin-converting-enzyme (ACE) (Figure 3) and glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (Figure 4). ACE is a component of the renin-angiotensin system, which regulates blood pressure,...
Formation of biofilms is a critical component of C. albicans pathogenesis [33] and the biofilm matrix provides a protective layer for the fungus against anti- fungal drugs [34]. The cargo of EVs produced by C. albicans biofilms includes key proteins and carbo- hydrates for biofilm biogenesis,...
Recently, PP1 was implicated in the dephosphorylation of HBV core protein (Cp), the main component of the HBV nucleocapsid [71], where pre-genomic RNA (pgRNA) is packaged and converted into viral DNA by DNA polymerase (DNA Pol) [72,73]. The Cp CTD is composed of eight conserved Ser ...
Multi-enzyme complexes designed based on scaffold proteins are a current topic in molecular enzyme engineering. They have been gradually applied to increase the production of enzyme cascades, thereby achieving effective biosynthetic pathways. This paper
These data indicate that GhAPm is a component of the CCVs, which participate in membrane trafficking, and that it is very important for cotton growth and development. As for anther and stigma, these tissues related to gamete development and fertilization, so cell metabolism and membrane ...