Docking is also used to predict protein-protein complexes, which are helpful in determining the quaternary structures of intrinsically multimeric proteins as well as to gain an understanding of the protein interaction networks. The objective of our research work is to predict protein ligand interaction...
Using high-temporal-resolution microscopy, we show that botrocetin decreases the GPIbalpha off-rate two-fold in both human and mouse complexes without affecting the on-rate. The key to this behavior is that, upon binding of GPIbalpha to vWF-A1, botrocetin prebound to vWF-A1 makes no ...
The development of entry inhibitors is hampered by the lack of crystal structures of the complexes involved. The most well-studied host factor is CD81, a transmembrane protein from the tetraspanin family, which interacts directly with E2 glycoprotein. Unfortunately, CD81 is ubiquitously expressed in...
Crystal structure of textilinin-1, a Kunitz-type serine protease inhibitor from the Australian Common Brown snake venom, in complex with trypsin. RCSB PDB entry 3D65, http://www.rcsb.org/rxplore/explore.do?structureId=3d65. Accessed 5 June 2013 Altschul SF, Madden TL, Schaffer AA, Zhang...
X-Ray crystal structures of complexes of the RC with atrazine (PDB entry 5PRC) and terbutryn (PDB entry 1DXR) have been determined at 2.35 and 2.00 Å resolution, respectively. In both cases, three hydrogen bonds bind the distal side of the inhibitors to the protein, and four additional...
The R-SNARE Motif of Tomosyn Forms SNARE Core Complexes with Syntaxin 1 and SNAP-25 and Down-regulates Exocytosis. Tomosyn is a 130-kDa syntaxin-binding protein that contains a large N-terminal domain with WD40 repeats and a C-terminal domain homologous to R-SNAREs. Her... Hatsuzawa,Kiyota...
Similar complexes have been described between toxins from snake venom and A1BG-like plasma proteins from opossum species. In these cases, complex formation inhibits the toxic effect of snake venom metalloproteinases or myotoxins and protects the animal from envenomation. We suggest that the A1BG−...
Results and discussion Finding disulphide-bonded loops at protein-protein interfaces To identify short disulphide bonded loops that play a cru- cial role at Protein-Protein Interfaces, we set out to find known three-dimensional structures of protein complexes mediated by a disulphide bonded loops. We...
information about protein interactions is gathered from the scientific literature and shown in the “general annotation” section under the heading “subunit”. There, one finds detailed information about binary interactions between proteins, but also about the composition of protein complexes, and about...
Fas is a snake toxin from the venom of the green mamba that inhibits the enzyme, AChE, responsible for the breakdown of the neural transmitter acetylcholine. Effects of mutations and ionic strength on the binding affinities of these complexes have been studied recently (Dong et al., 2003, ...