7). We also calculated the two-dimensional (2D) free energy landscapes by defining the order parameters n1 and n2, corresponding to the degree of structure formation in the N- and C-terminal halves of each protein, respectively, as follows: $$\left\{\begin{array}{c}{n}_{1}=\frac{1...
C-terminal domain (CTD) of RNA-polymerase II and N-terminal segment of the human TATA binding protein (TBP) can mediate remote and proximal transcriptional... High mobility protein-1 (HMG-1) has been shown to regulate transcription by RNA polymerase II. In the context that it acts as a ...
Parathyroid hormone-related protein (PTHrP) is synthesized by diverse tissues, and its processing produces several fragments, each with apparently distinct autocrine and paracrine bioactivities. In bone, PTHrP appears to modulate bone formation in part t
XP-C; XP3; XPCC; RAD4; Xeroderma Pigmentosum Group C Protein; DNA repair protein complementing XP-C cells来源:原核表达宿主:E.coli内毒素水平:<1.0EU/µg(LAL法测定)亚细胞定位:n/a预测分子量:实际分子量:-(差异分析请参阅说明书)片段与标签:N-terminal His Tag缓冲...
PrPC shows an interesting modular structure: an extended intrinsically disordered N-terminal domain and a highly structured C-terminal domain of a similar length (Fig. 1A). Various approaches in transgenic mice and cultured cells, including primary neurons, revealed that the N-terminal domain ...
作者: Chong, Yuh-Ping,Mulhern, Terrence D.,Cheng, Heung-Chin 摘要: C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK) are endogenous inhibitors of the Src-family protein tyrosine kinases (SFKs). Since constitutive activation of SFKs contributes to cancer formation and progression, to...
c-Jun N-terminal kinase inhibitor favors transforming growth factor- to antagonize hepatitis B virus X protein-induced cell growth promotion in hepatocellu... c‑Jun N‑terminal kinase inhibitor favors transforming growth factor‑β to antagonize hepatitis B virus X proteininduced cell growth ...
Our investigations reveal that the N-terminal 20 residues of SmpB, which are located near the ribosomal decoding center, are dispensable for all known SmpB activities. In contrast, a set of conserved residues that reside at the junction between the tmRNA-binding core and the C-terminal tail of...
(Fig.4a, b). The C-terminal STK domain of Pm13 was composed of a smaller N-lobe made up of five antiparallel β strands and the helix αC, and a larger C-lobe composed principally of α helices (Fig.4a, c), and the two domains were connected by a three helices-containing brace ...
(Fig.6B). The C-terminal 10 residues were invisible in the electron density map, and therefore, residues Q28-G161 were modeled. The crystal belongs to the space groupC2 and contains a single PorA-N molecule in an asymmetric unit. The structure of PorA-N adopts an immunoglobulin-like fold...