C-reactive protein (CRP) is a marker of inflammation in the body. Therefore, its level in the blood increases if there is any inflammation in the body. C-reactive protein, along with other markers of inflammation (erythrocytesedimentation rate, "sed rate," orESR) are also sometimes referred ...
Chemicals are measured regularly in air, food, the environment, and the workplace. Biomonitoring of chemicals in biological fluids is a tool to determine the individual exposure. Blood protein adducts of xenobiotics are a marker of both exposure and the biologically effective dose. Urinary metabolites...
Ping et al.56. All samples were then analyzed on the Evosep One system using the preprogrammed 21-min gradient as described by Bekker-Jensen et al.57. MS was performed with a high-field asymmetric waveform ion mobility spectrometry Pro equipped Orbitrap Eclipse (Thermo) in positive ion mode u...
Aliquots of mouse liver lysates were processed with the FASP method, and the residual high-molecular-weight material was sequentially cleaved with RNase and DNase (labeled “samples digested with DNase and RNase”). The released ribo- and deoxyribonucleotides were quantified spectrophotometrically at ...
which implies higher-order regulatory rules for not only 1D but also 3D DBP cooperation. One major limitation of this work is that it relies on high resolution Hi-C data that is only available in a limited number of cell types. Furthermore, the chromatin loops used in this project are tak...
In conclusion, this study demonstrates that use of a very high protein, low carbohydrate formula is associated with a reduced glycemic response in subjects with type 2 diabetes. The formula may assist in improving blood glucose management in long term enterally fed subjects with type 2 diabetes....
(width: 0.3, downshift 1.8). Volcano plots comparing TEV eluates of targeted affinity enrichment with K12 wildtype mock enrichment were created using a two-sided, two-samplet-test with 1% FDR and an artificial variance S0 of 2. For high-resolution figures, the matrix and the cut-off curve...
“highway” in our work. As examples, the M3R GPCR can activate β-arrestins in addition of the heterotrimeric Gq protein25; additional effectors of Gαq-GTP and Gβγ released from the Gq heterotrimer exist in addition to PLCβ34; and the second messenger IP3possesses other signaling ...
Uncovering the pharmacology of the G protein-coupled receptor GPR40: high apparent constitutive activity in guanosine 5′-O-(3-[35S]thio)triphosphate binding studies reflects binding of an endogenous agonist. Mol. Pharmacol. 71, 994–1005 (2007). CAS PubMed Google Scholar Poitout, V. & ...
G. et al. Monoacidic inhibitors of the Kelch-like ECH-associated protein 1: nuclear factor erythroid 2-related factor 2 (KEAP1: NRF2) protein–protein interaction with high cell potency identified by fragment-based discovery. J. Med. Chem. 59, 3991–4006 (2016). Article CAS PubMed Google...