Many of them could not be targeted by traditional inhibitors due to their structural complexity, off-target effects and so on. Second, traditional inhibitors only block part of the protein’s function, while PROTACs degrade the protein, thus eliminating all its functions. Third, traditional kinase...
However, despite more than four decades of study, we still do not understand much about its physiological mechanisms of action. This review examines the published literature with a critical eye. This review aims to (a) provide background on the chemistry of disulfide bond formation and ...
Deciphering the relationship between a gene and its genomic context is fundamental to understanding and engineering biological systems. Machine learning has shown promise in learning latent relationships underlying the sequence-structure-function paradig
A Survey of Deep Learning Methods in Protein Bioinformatics and its Impact on Protein Design [arXiv:2501.01477] From thermodynamics to protein design: Diffusion models for biomolecule generation towards autonomous protein engineering [arXiv:2501.02680] • review Improving functional protein generation...
Protein sequence contains clues to its function. Functional prediction from sequence presents a challenge particularly for proteins that have low or no seq... L Han,J Cui,H Lin,... - 《Proteomics》 被引量: 74发表: 2010年 Functional overlap between conserved and diverged KH domains in Saccharo...
Number of constitutive (blue) and alternative (red) regions in the longest isoform. The fraction of completely alternative genes is ~1%. Full size image We considered the link between protein function and the isoform number. The following functional categories from GO were considered: "Small GTPase...
The model includes five modules: Input, Tokenizer, Encoder, Pooling, and Output. Its architecture is shown in Figure 1. Figure 1 The Architecture of LucaProt 3) Model Input/Output Use the amino acid letter sequence as the input of our model. The model outputs the function label of the ...
in a number of chromosomal translocations causing 5–10% acute leukemia in children and adults with a poor prognosis [10,20]. We summarize the biology, structures, structure–function relationships and inhibition of the critical PPIs involving MLL1 as well as its major fusion proteins (Fig.1c)...
AlphaFold 2: Why It Works and Its Implications for Understanding the Relationships of Protein Sequence, Structure, and Function. 来自 Semantic Scholar 喜欢 0 阅读量: 129 作者:J Skolnick,M Gao,H Zhou,S Singh 摘要: AlphaFold 2 (AF2) was the star of CASP14, the last biannual structure ...
Evaluating the effects of point mutations on protein association rates. To systematically validate the sensitivity of our simulation algorithm and scoring function, we tested the effect of protein mutations on the calculated association rates. Mutations of specific residues at binding interfaces change...