Since then, this process has emerged as a controller of histone and nonhistone acetylation that integrates key physiological processes such as metabolism, circadian rhythm and cell cycle, along with gene regulation in various organisms. The widespread and reversible nature of acetylation also revitalized...
FAP is an integral membrane protein that exists as a 170-kDa homodimer and is also found in human serum as a soluble form lacking the transmembrane domain. FAP is expressed at sites of tissue remodeling25 and also activates the hepatic stellate cells26. Recent reports have shown that human ...
Figure 1. Pathways for plasmalogen metabolism in macrophages. Similar to monoacylglycerophospholipids, lysoplasmalogens are amphiphiles that can insert into phospholipid bilayer membranes and alter membrane structure and function. At levels near to and above their critical micelle concentration, amphiphiles ca...
The gut microbiota has been gaining increasing attention as an important contributor to maintaining host health by regulating host metabolism and immunity1,2. Communication between the host and gut microbiota is mediated by microbiota-derived bioactive molecules, such as surface proteins, secreted proteins...
Fig. 6. A proteomic view of skeletal muscle metabolism. A, Schematic representation of glucose and lipid metabolism in skeletal muscle. B, Summed absolute abundance of glucose transporters (GLUT) and fatty acid transporters (FAT). C, Absolute abundance of glycogen synthase (Gys), glycogen phosphor...
(epinephrine and norepinephrine). Furthermore, CA activates protein kinase A (PKA) via adrenoreceptors (ARs), such as β3-AR. Subsequently, PKA significantly impacts UCP1 activity by orchestrating various cellular processes. These include AIDA, a protein containing a C2 domain known for its ...
NAE consists of catalytic subunit UBA3 (also known as NAEβ) and the regulatory subunit amyloid-beta precursor protein-binding protein 1 (APPBP1, also known as NAE1).38NAE activates NEDD8 to initiate neddylation process by recognizing the alanine 72 in NEDD8,4,27and continues the NEDD8 tran...
Metformin as a first-line clinical anti-diabetic agent prolongs the lifespan of model animals and promotes cell proliferation. However, the molecular mechanisms underlying the proliferative phenotype, especially in epigenetics, have rarely been reported.
IRE1 has been shown to extend lifespan in a cell-non-autonomous manner by remodelling lipid metabolism and promoting lipophagy16,18,19. Neuropeptide signalling originating from four glial cells is postulated to regulate ER stress resistance and longevity in C. elegans20. Although stress resistance ...
Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I Article Open access 20 July 2022 Primary oocytes with cellular senescence features are involved in ovarian aging in mice Article Open access 13 June 2024 The proteome, not the transcriptome, predicts that oocyte superovula...