Binding to site 1 (apparent K d 17 nM) shows positive cooperativity an... F Hofmann,HP Gensheimer,Claus GÖBEL - 《Eur J Biochem》 被引量: 45发表: 2010年 Covalent and noncovalent modifications induce allosteric binding behavior in a monoclonal antibody. Detailed equilibrium binding studies ...
In order to treat cancer, we provide an antibody drug binding (ADC) that binds to the protein. Solution: a 191 p4d12 antibody or a light chain variable region containing CDR having an amino acid sequence of a light chain variable region CDR shown in another specific amino acid sequence and...
Consisting of recombinant proteins fused to an IgG binding site, these versatile molecular weight ladders bind the primary or secondary antibody used for the detection of the target protein. Western blotting ladders provide a useful positive control to evaluate ...
Protein L has the unique ability to bind through kappa light chain interactions without interfering with the antibody's antigen-binding site. This gives Protein L the ability to bind a wider range of Ig classes and subclasses than other antibody-binding proteins. Amino Acid Sequence KEETPETPET ...
BOSTROM J,YU SF,KAN D,et al. Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site[J]. Science,2009,323( 5921) : 1610 - 1614. Anuradha Krishnamurthy , Antonio Jimeno,Bispecific antibodies for cancer therapy: A review,Pharmacol Ther . 2018 May;185...
monoclonal antibody 42–1. The following secondary antibodies were used: goat-anti-rabbit IgG AP (ELISA-1:1000; Southern Biotech, 4049–04), goat-anti-rabbit IgG DyLight 800 (WB-1:10000; ThermoFisher Scientific, SA5-35571), goat-anti-mouse IgG Alexa Fluor 680 (WB-1:10,000; Thermo...
It allows for easy access to curated, annotated, and classified antibody structures SKEMPI v2.0 SKEMPI 2.0 is a database of experimental measurements of the change in binding free energy caused by mutations in protein-protein complexes ProtCAD ProtCAD is a suite of tools for the design and ...
Consisting of recombinant proteins fused to an IgG binding site, these versatile molecular weight ladders bind the primary or secondary antibody used for the detection of the target protein. Western blotting ladders provide a useful positive control to evaluate the performance of the ...
Bacterial Immunoglobulin-Binding Proteins Michael D.P.Boyle, inEncyclopedia of Immunology (Second Edition), 1998 Summary Immunoglobulin-binding proteins represent a family of diverse molecules capable of interacting with antibody without impairing the ability of the antibody to bind its cognate antig...
Selection of antibody-binding covalent aptamers Noah Soxpollard Sebastian Strauss Iain S. MacPherson Communications Chemistry (2024) Sulfur (VI) fluoride exchange (SuFEx): a versatile tool to profile protein-biomolecule interactions for therapeutic development Lingyun Yang Zhengnan Yuan Bingchen Yu ...