When the model predicts that a DHF epidemic was forthcoming,a highly effective but low-cost DEET product was applied to the whole family as protection againstmosquito bites. It was found that the cost of implementing such model prediction was much cheaperthan other options such as: (i) using ...
Dengue fever, transmitted by the bite of an infected Aedes mosquito, poses a significant public health challenge globally. The reason protection against dengue is paramount stems from its potentially severe complications. ZiKa Protection against Zika virus is crucial due to its potential to cause serio...
Neutralizing antibodies (nAbs) are essential for protection against dengue in both natural infections and vaccine trials5,7. The composition and magnitude of pre-existing nAbs can vary depending on the previous infecting serotype and number of previous infections2. The current “gold standard” to as...
An inactivated dengue virus vaccine to immunize and protect humans against dengue fever is described. The vaccine is based on dengue viruses which have been propagated to high titers in suitable cells, purified and inactivated under conditions which destroy infectivity but preserve immunogenicity, a hig...
Yellow fever virus/dengue-2 virus and yellow fever virus/dengue-4 virus chimeras: biological characterization, immunogenicity, and protection against dengu... Two yellow fever virus (YFV)/dengue virus chimeras which encode the prM and E proteins of either dengue virus serotype 2 (dengue-2 virus...
more modular. Chubb has developed a set of application programming interfaces that allow its partners to easily integrate Chubb’s insurance products into their platforms. DBS Bank in Singapore, for example, used Chubb Studio to develop and deploy Mozzie Protect, insurance against deng...
The activity of ATM is required for virus-induced autophagy and protection against CPT. (a) Caffeine (Caf), an inhibitor of ATM, decreases autophagy, as indicated by the decrease in the smaller LC3 band, in Dengue (Den)-infected cells (compare Den Caf with Den) after 24 h. (b) Caff...
First consider vaccination as the sole personal protection strategy available against cholera. The clean water consumption rate is thus set at \(r=0\) in our epidemiological model (2). The threshold value of the vaccination rate necessary to achieve herd immunity is obtained by setting the basic...
Wistar Institute, Philadelphia, USA, generated a DNA-based vaccine candidate using genes encoding for Zika virus surface proteins—with the intent that these genes, when transferred to a host, would produce characteristic proteins allowing the host to recognise and protect against Zika virus infection...
Disease tolerance is an evolutionarily conserved defence strategy against infection that does not exert a direct negative effect on the host pathogen load. Disease tolerance relies on tissue damage control mechanisms. Tissue damage control mechanisms rely on stress and damage responses. Innate and adaptiv...