This will be a placebo-controlled adaptive multi-center randomized controlled trial. A total of 1800 individuals considered to be at high risk, including those with comorbidities (hypertension, diabetes, obesity, reactive airway disease, smokers), racial and ethnic minorities, elderly, teachers, police...
Croup was diagnosed by physicians during clinical examinations and medical record checks. Potential mediating mechanisms were investigated using blood metabolomics, airway cytokines and airway microbiome.Results: A total of 97 of 695 children (14%) had croup before age 3 years. The risk of croup ...
6b). Clinical lung cancer commonly has distinct oncogenic mutations such as p53/EGFR/KRAS2. H1299 tumour cells (with p53 deletion) were co-injected with hCAF-mock or hCAF-ZIP1 into NOD-SCID mice. With paclitaxel treatment, the growth of hCAF-mock H1299 tumours was slower than that with...
Multiple respiratory microbiota profiles are associated with lower airway inflammation in children with protracted bacterial bronchitis. Chest 2019;155:778–86. Article PubMed Google Scholar Stewart CJ, Mansbach JM, Ajami NJ, Petrosino JF, Zhu Z, Liang L, et al. Serum metabolome is associated ...
In addition, PD1 also displays potent and interesting neuroprotective effects in neuronal systems [7], and this SPM has entered clinical trial development programs [18]. The established biochemical pathways of the protectins will be discussed in detail (vide infra), but also the metabolites and ...
Vitamin D deficiency decreases the expression of VDR and prohibitin in the lungs of mice with allergic airway inflammation. Exp Mol Pathol. 2012; 93:7481. [PubMed: 22537547] 46. Finklea JD, Grossmann RE, Tangpricha V. Vitamin D and chronic lung disease: a review of molecular m...
After incubation for 24 h, when the cells had adhered to the surface of the vessel, Airway Epithelial Cell Growth Medium was replaced with fresh medium containing the appropriate factors. After incubation for 1 h, the S protein was added at a concentration of 2 µg/mL to the culture ...
Tracheal intubation provides the most secure and reliable airway.1 If a cuffed endotracheal tube (ETT) is used with a High Efficiency Particle Arresting (HEPA) filter, the resulting closed-circuit carries a lower risk of aerosolization than any other method.2 Alternatively, the supraglottic airway...
On day 3 and 5 post Omicron challenge, no evidence of pulmonary pathology was noted in the lower airway in any of the control animals, however minimal subacute inflammation and multifocal necrosis was noted in the trachea of 2/4 and 1/4 control animals on day 3 and 5, respectively. SARS...
and airway epithelial cells (ECs). ECs in particular can influence the functions of local immune cells via the expression of a wide range of molecules, including MHC-I and MHC-II, costimulatory molecules, chemokines, cytokines, and prostaglandins. During the past few years, a particular interest...