Proteasome DegradationDefinitionDefinitionProteasome degradation is the degradation of proteins mediated by a multi-subunit complex of proteases within a cell; ubiquitination.Springer Berlin Heidelbergdoi:10.1007/3-540-30683-8_1387
Time-dependent quantification of the degraded Ubn–Sic1PYsubstrate indicates that USP14 reduced the degradation rate by approximately two-fold compared with that of the USP14-free proteasome7(Extended Data Fig.1k). The majority (about 80%) of substrates were eventually degraded by the USP14–prot...
Fig1. Structure, function, and substrate profile of the proteasome degradation pathway. A, Components of the UPS and the UIPS. B, Diagram of substrate turnover by the different proteasome pathways. The 26S proteasome degrades over 90% of the proteome, including IDPs and folded proteins, by...
翻译 proteasome 英[prəʊti:'sɒm] 美[proʊti'sɒm] 释义 [医]蛋白酶体 实用场景例句 全部 Ubiquitin -proteasomepathway is a highly effective protein - degradation pathway in the eukaryotic cells. 泛素- 蛋白酶体途径是真核细胞内一种高效蛋白降解途径. ...
Here, for the first time we demonstrate that E6 associated protein (E6AP), an E3 ubiquitin ligase physically associates with G-CSFR and targets it for ubiquitin-mediated proteasome degradation and thereby attenuates its functions. We further show that E6AP promoted G-CSFR degradation leads to ...
Another potential hypothesis is that enhanced proteasome activity of hESCs is not directly linked to the degradation of endogenous substrates. In this model, increased proteasome activity could be coupled with intrinsic characteristics of pluripotent stem cells. In support of this hypothesis, we observed...
4.Huang HL, Weng HY, Wang LQ, Yu CH, Huang QJ, Zhao PP, Wen JZ, Zhou H, Qu LH. Triggering Fbw7-mediated proteasomal degradation of c-Myc by oridonin induces cell growthinhibition and apoptosis. Mol Cancer Ther. 2012 May;11(5):1155-65.5.Wang D, Fang L, Li K, Zhong H, Fan J...
Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts One of the highlights of age-related changes of cellular metabolism is the accumulation of oxidized proteins. The aging process on a cellular level can be ... Nicolle,Sitte,and,... - 《Free Radical Biolog...
Genomic alterations may make cancer cells more dependent than normal cells on mechanisms of proteostasis, including protein folding and degradation. This proposition is the basis for the clinical use of proteasome inhibitors to treat multiple myeloma and
L. et al. Competition between decapping complex formation and ubiquitin-mediated proteasomal degradation controls human Dcp2 decapping activity. Mol. Cell Biol. 35, 2144–2153 (2015). CAS PubMed PubMed Central Google Scholar Kelly, S. P. & Bedwell, D. M. Both the autophagy and ...