Intracellular proteolysis is an essential process (1). The ubiquitin—proteasome pathway represents a strictly controlled complex enzymatic machinery for nonlysosomal protein degradation in eukaryotic cells. Thus, it is particularly important for the tur
The proteasome is a multicatalytic proteinase complex with a highly assembled ring-shaped 20S core structure which is composed of 4 rings of 28 non-identical subunits, 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are found throughout eukaryo...