Proteasome 20S LMP7 抗体 | MCE 英文名称: 总访问: 50 国产/进口: 进口 半年访问: 11 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 10 μL 最后更新: 2025-2-13 货号: HY-P80437 CAS 号: 参考报价: 470 立即询价 电话咨询 ...
上海玉博生物科技有限公司 主要致力于“Proteasome 20S β5i subunit, mAb (LMP7-1) BML-PW8845-0100”的生产销售。多年的“Proteasome 20S β5i subunit, mAb (LMP7-1) BML-PW8845-0100”生产与销售的经验,与各行业新老用户建立了稳定的合作关系,我公司经营的产品名称深
1996. 20S proteasome from LMP7 knock out mice reveals altered proteolytic activities and cleavage site preferences. FEBS Lett. 383: 109 -113.Stohwasser R, Kuckelkorn U, Kraft R, Kostka S, Kloetzel P- M. 20S proteasome from LMP7 knock out mice reveals altered proteolytic activities and ...
J. et al. MHC class I expression in mice lacking the proteasome subunit LMP-7. Science 265, 1234–1237 (1994). Wolf-Levy, H. et al. Revealing the cellular degradome by mass spectrometry analysis of proteasome-cleaved peptides. Nat. Biotechnol. 36, 1110–1116 (2018). Article CAS MATH ...
Epoxomicin 通过共价结合方式与蛋白酶体的LMP7、X、MECL1和Z催化亚单位结合。Epoxomicin(100 nM)使已知的蛋白酶体靶标蛋白p53的水平提高30倍,在HUVECs中产生显著效果。Epoxomicin(10 μM)导致在HeLa细胞中泛素化蛋白的堆积。同时,Epoxomicin(10 μM)使HeLa细胞中的IκBα降解减缓10倍,并显著剂量依赖性地降低了TNF...
during 20S Immunoproteasome assembly, the three catalytic beta subunits, beta 1, 2, and 5, in the two interior rings of the 20S Proteasome are replaced by three IFN-gamma-inducible catalytic subunits: beta 1i/LMP2, beta 2i/LMP7, and beta 5i/MECL-1. The 20S Immunoproteasome is commonly...
Borissenko L, Groll M (2007). 20S proteasome and its inhibitors: crystallographic knowledge for drug development. Chem Rev 107:687–717 ArticlePubMedCASGoogle Scholar Braun BC, Glickman M, Kraft R, Dahlmann B, Kloetzel PM, Finley D, Schmidt M (1999) The base of the proteasome regulatory...
It is composed of two subcomplexes: a barrel-shaped 20S core particle containing the protease active sites and two 19S regulatory particles that cap the barrel and control access of substrates to the core. Nuclear factor-κB (NF-κB). A transcription factor with a key role in regulating the...
20S IFNγ-inducible or immunoproteasomeβ1i/PSMB9/LMP2, β2i/PSMB10/MELC1, β5i/PSMB8/LMP7 11S activator or REG11Sα/PA28α/PSME1, 11Sβ/PA28β/PSME2, 11Sγ/PA28γ/PSME3 OthersProteasome maturation protein (POMP) IFNγ, interferon γ;LMP2, low-molecular-weight protein 2;LMP7,...
Conversely, three solvent-facing regions of the α-ring were significantly more dynamic/accessible in the std20S than in the i20S (Fig. 4d in blue, Supplementary Data 4, 7). Since these constitute potential binding sites for the proteasome regulators, this could explain the preferential ...