Men in the highest category of average lifetime ejaculation frequency were less likely to have a family history of prostate cancer and a history of surgery for enlarged prostate than men in the lower categories of ejaculation frequency. Men in the highest and lowest categories had a lower ...
Proteins enter the urine in two ways: leakage at the glomeruli of the kidney and throughout the urogenital tract. It is believed that the vast majority of the excreted urinary proteome derives from tissues of the genitourinary tract, rather than leakage from the kidneys. Urogenitary proteins can...
types have suggested B cells and plasma cells in the TME are significant biomarkers for predicting immunotherapy responsiveness10,23,25. For men with PC receiving immunotherapy in the form of sipuleucel-T, treatment response correlates with induced elevated serum levels of anti-tumor IgG and, ...
Among both urologists and radiation oncologists, radical prostatectomy, external beam radiotherapy, and brachytherapy have all been considered the treatment of choice. Brachytherapy and external beam...
[111] on the other hand, employed PAM50 to classify PCa cells into two types and found that patients with luminal B tumors showed a poor prognosis but better response to postoperative ADT compared to those with non-luminal B tumors, suggesting the more accurate use of postoperative ADT. ...
All six comparisons for the MSKCC, CancerMap, Stephenson, and Klein datasets are shown. The expression levels of each gene have been normalised across all samples to mean 0 and standard deviation 1. (D) Kaplan-Meier PSA failure plots for the MSKCC, CancerMap, and Stephenson datasets. BCR =...
Chromoplexy is evident in several solid tumor types and in the majority of prostate cancers. In multiple instances, chromoplexy altered more than one cancer gene coordinately. In the future, systematic assessment of chromoplexy from WGS data could reveal groups of cancer gene alterations that ...
Association between radiation therapy, surgery, or observation for localized prostate cancer and patient-reported outcomes after 3 years. JAMA. 2017;317(11):1126-1140.ArticlePubMedGoogle ScholarCrossref 12. Gómez-Gómez E, Carrasco-Valiente J, Blanca-Pedregosa A, et al. European Randomized Study...
Dense-2 U-net was able to discriminate between the two tissue types and kept the border lines as close as possible to the ground truth. The second patient (see Fig.10second row) was a Transurethral resection of the prostate (TURP) where the patient undergoes a surgery to shave the excess...
The treatment of low-risk primary prostate cancer entails active surveillance only, while high-risk disease requires multimodal treatment including surgery, radiation therapy, and hormonal therapy. Recurrence and development of metastatic disease remains