The gut microbiota modulates response to hormonal treatments in prostate cancer (PCa) patients, but whether it influences PCa progression remains unknown. Here, we show a reduction in fecal microbiota alpha-diversity correlating with increase tumour burden in two distinct groups of hormonotherapy naïv...
In addition, any estimates of effect size would, necessarily, be imprecise. This resulted in assigned grades of "insufficient" for all six comparisons of PCA3 with tPSA, free PSA, PSA velocity, PSA density, complexed PSA, and externally validated nomograms. Furthermore, strength of evidence31 ...
Fourth, a relatively large sample size (n = 2060) was used and was representative of the population of men with prostate cancer in 2 states, Louisiana and North Carolina; therefore, it has a good potential for the detection of small differences and for generalizability of the results. Fifth,...
(SG and OD) from each paper and entered in a dedicated spreadsheet: first author, year of publication, period of enrolment, country, study design, sample size, risk estimates and their 95% confidence intervals (CI; or another measure of statistical uncertainty, like standard errors or exactp-...