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Full size image Iron metabolism in PCa Transferrin-mediated and lactoferrin-mediated iron uptake pathways are the main pathways for cells to take up iron, after binding to iron, the two proteins enter cells through corresponding receptor/non-receptor pathways [7]. In PCa, to provide cancer cells...
Full size image Next, we tested if our observations would also translate into an in vivo setting. For this purpose, we injected LNCaP cells into the flank of immune-compromised mice and treated the emerging xenograft tumors with castration alone or in combination with 3 weeks of GSK126. In bo...
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Hotspots where genes are interrupted by >50% breakpoints or recurrent in >50% genomes are labelled Full size imageAll identified SV hotspots included multiple SV types (Fig. 3A). 12 hotspots contained >50% deletions of all SV events within the bin, including the ...