A flow chart in this study workflow. PSA: prostate-specific antigen; PC: prostate cancer; DCE-MRI: dynamic contrast-enhanced MRI; DWI: diffusion-weighted imaging; PZ: peripheral zone; TZ: transition zone; PI-RADS: Prostate Imaging Reporting and Data System Full size image 2.6 Statistical analys...
b. The decision for prostate biopsy should be based on PSA levels and/or suspicious findings from DRE and/or imaging studies, with consideration given to age, underlying comorbidities, and treatment response. Ultrasound-guided transrectal or transperineal biopsy is the standard approach. For baseline...
The interpretation of the PSA result must be done with care. PSA results must be, for example, interpreted in the context of the patient's age. Younger men (under 70 years of age and definitely under 60 years of age) may have either more aggressive prostate cancers or live long enough t...
The interpretation of the PSA result must be done with care. PSA results must be, for example, interpreted in the context of the patient's age. Younger men (under 70 years of age and definitely under 60 years of age) may have either more aggressive prostate cancers or live long enough t...
s cellular architecture, which in turn can result in PSA leaking into circulating blood. However, PSA levels can also be affected by benign prostatic hyperplasia (BPH), local inflammation or infection, prostate volume, age2, and germline genetics. In this regard, PSA is an organ—but not ...
Patients selection flow chart Full size image Table 1 Baseline Characteristics of Patients with Negative mpMRI. Full size table Univariate logistic regression analysis indicated that older age, higher PSA levels, lower f/tPSA ratio, smaller prostate volume, and higher PSAD were all significantly assoc...
On the right to the cladogram, plasma total prostate specific antigen (PSA) levels are placed on the timeline in dark gray, together with corresponding percent free PSA values in light gray when available. GP5 received dutasteride and finasteride for symptoms of benign prostatic hyperplasia during...
Cumulative incidence curve for prostate cancer-specific mortality (PCSM) by obesity groups. overweight and 1372 (32%) were obese. A higher BMI was associated with younger age at surgery (Po0.001), lower PSA (median 7.1 vs 6.3 vs 6.1; Po0.001), and a shorter follow-up time (P = 0.050...
If the PSA level is elevated (levels can depend upon your age, on the size of your prostate gland on examination, certain medications you may be taking, or recent sexual activity) or has increased significantly over time, further testing may be needed to rule out prostate cancer. ...
Age, Prostate Volume, Prostate Specific Antigen (PSA) levels, Gleason Score, Pathological Tumor Stage (pT stage), and the expression level of circKIF18B_003. Age and Prostate Volume were included as general patient characteristics that could potentially influence the disease course. PSA levels, Gle...