After 29 months, 136 patients in the ADT-only group died compared with 101 men in the group who received both drugs. The median overall survival was 57.6 months for patients receiving early chemotherapy compared with 44 months in the group where ADT was the only initial treatme...
Androgen deprivation therapy (ADT) is standard frontline therapy for metastatic prostate cancer. However, prostate cancer progresses to a castrate-resistan... Nima,Sharifi,Elaine,... - 《Cancer Chemotherapy & Pharmacology》 被引量: 29发表: 2008年 加载更多研究...
Side bar: My Dad's long-time partner, Gwyn, will tell you that her first husband Jack suffered terribly for years while fighting cancer in the 90's, and if she had it to do over again, they both would have refused the Chemotherapy and Radiation, each of which destroy healthy tissue wh...
None of the patients had been treated with chemotherapy, radio- therapy, or other anticancer therapies before surgery. The status of lymphatic metastasis was determined by the pathological examination. All tissue specimens were stored in liquid nitrogen for subsequent total RNA or protein isolation. ...
A Phase II Study of Preradiation Chemotherapy Followed by External Beam Radiotherapy for the Treatment of Patients with Newly Diagnosed Glioblastoma Multif... Recent publications support the use of preradiation chemotherapy in the treatment of selected primary brain tumors. In the pediatric population,...
Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J Clin Oncol. 2005;23(10):2346–57. PubMed Central CAS PubMed Google Scholar Morgan RA, Dudley ME, Wunderlich JR, Hughes MS, Yang JC, ...
Androgen deprivation therapy (ADT) alone or combined with radio- and/or chemotherapy has long been used as treatment of choice for PCa3. However, over time a significant population of patients loses responsiveness to ADT and develops hormone-refractory prostate cancer (HRPC)4. Due to the ...
Conclusions: Adverse events of cytopenias and alopecia were lower with ModraDoc006/r, and preliminary efficacy appears comparable in both arms. Oral chemotherapy option has become critically important during the COVID-19 pandemic. Preliminary data reveals that ModraDoc006/r is an attractive oral ...
Taxane-based chemotherapy used to be restricted to the hormone-resistant metastatic setting. Unfortunately, most patients with castration-resistant prostate cancer (CRPC) rapidly develop resistance to chemotherapy. Recently, two trials demonstrated increased survival in men with high-risk metastatic hormone...
Results: From Apr 2016 to Sep 2018, a total of 197 patients (median age 67 years, range 4580; visceral metastases in 29 patients; previous chemotherapy history in 80 patients) were enrolled (phase 1, n = 18; phase 2, n = 179). No dose-limiting toxicities were reported and the ...