Prostate cancer is the second most common malignancy in men worldwide and consists of a mixture of tumor and non-tumor cell types. To characterize the prostate cancer tumor microenvironment, we perform single-cell RNA-sequencing on prostate biopsies, prostatectomy specimens, and patient-derived organo...
sexual changes, did not experience a challenge to identity, and engaged in sexual re-negotiation. The nature of GB relationships, wherein many men are single, engage in casual sex, or have concurrent partners, influenced experiences of distress, identity, and renegotiation. It is concluded that ...
He shared Black men have a 70% higher rate of developing high-risk prostate cancer and they are also more than twice as likely to die from it. It's the second most common form of cancer in men. "I think it's very important for men to pay attention because it's a real threat," ...
The naming convention for PDXs is a follows: numbers indicate patient ID and tumor site (e.g., 167.1 is patient 167, site 1), letters denote the sample source (R—radical prostatectomy; M—biopsy or surgical sample of metastasis; C— castration-resistant primary tissue; A—autopsy tissue),...
References should include, in order, authors' surnames and initials, article title, abbreviated journal name, year, volume and inclusive page numbers. The last names and initials of all the authors up to 6 should be included, but when authors number 7 or more, list the first 6 authors only...
Body image, self-esteem, and masculinity are three interconnected constructs in men with prostate cancer, with profound effects on quality of life. This me
primary and secondary numbers together to form your total Gleason score. That tells you how aggressive the cancer is. The lowest score for a cancer is 6, which is a low-grade cancer. A Gleason score of 7 is a medium-grade cancer, and a score of 8, 9, or 10 is a high-grade ...
The TWIST1 hypo-phosphorylation mimetic overexpressing Myc-CaP cells exhibited greatly reduced potential to form macroscopic lung metastases in vivo, and metastasis numbers were indistinguishable from Vector control Myc-CaP lungs (Figure 5, A and B, 2 of 12 mice injected with Twist1-AQA ...
All numbers (those provided so far and those following) were obtained using cross-entropy as the main loss function, while Table3shows a comparison for all three losses (focal, cross-entropy, and Dice) that were used to optimize the network. ...
response complex (which includes the Hsp90 chaperone protein targeted by several drugs in development) raises the possibility that these cellular processes may represent targetable dependencies in some prostate tumours. Overall, complete genome sequencing of large numbers of relapsing primary and metastatic...