Pathological severity of prostate adenocarcinoma, despite progress with molecular markers and MRI, is generally scored according to the Gleason grading (Gs) system, which uses histological data only, frequently complemented with PSA measurement in blood and tumor staging21. However, this classification me...
One of those most important innovations, has been MRI fusion, meaning we get MRIs prior to our ultrasound guided biopsies. But at the end of the day, we still need that ultrasound in order to obtain the tissue for the biopsy. Traditionally, the ultrasound has always been placed in the ...
(MRI), or fluorodeoxyglucose (FDG) positron emission tomography–`CT (PET-CT). PSMA PET-CT was not used as a sole criterion to define metastasis. HSPC was defined as the absence of ADT use from the time of diagnosis to the sampling date or for the past two years, or it was defined ...
USA). For the determination of statistical significance, Student’stand Fisher’s exact tests were used for continuous and categorical variables, respectively. When analyzing data with multiple comparisons, a correctedpvalue with application of the Bonferroni multiple comparison procedure was used. Statisti...
3.1.4. Synthesis of Peptide 6 (Hydrazine-Glutarate-GG-VCit-C6-[CTVRTSADC]) The synthesis of peptide 6 was followed by using a similar procedure described in 3.1.3 upto the coupling of Fmoc-6-Ahx-OH, and then Fmoc-L-citrulline-OH (Cit; 476 mg, 1.2 mmol) and Fmoc-Val-OH (305 ...
The Mann–Whitney U test was performed on both metabolomics and lipidomics datasets with the Benjamini–Hochberg procedure to control the false discovery rate (FDR) [39]. Principal component Metabolites 2019, 9, 82 16 of 18 analysis (PCA) plots were generated using MetaboAnalyst 4.0 [40]. ...