23.15). There is no definite basal lamina, but a layer of very vascular and elastic connective tissue surrounds the gland to form a capsule which sends broad radiating trabeculae into its substance. The interalveolar tissue consists of dense connective tissue, with collagen and elastic networks, ...
Part I: Stem Cells, Telomerase Biology, and Systemic Therapy to Provent Tumor Progression Robert D. Loberg Ph.D., ... Kenneth J. Pienta M.D., in Urologic Oncology: Seminars and Original Investigations, 2006 The lack of appropriate, clinically relevant, cell-based model systems has limited ...
Prostate cancer is a very prevalent disease in men. Patients are monitored regularly during and after treatment with repeated assessment of prostate-specific antigen (PSA) levels. Prognosis of localised prostate cancer is generally good after treatment,
As Tn expression has been detected in up to 90% of prostate tumours [58, 65,66,67] there is huge potential to exploit this biology to benefit patients. The absence of a glycosylation consensus sequence and the variability of glycan elaboration have historically made O-GalNAc glycans challenging...
Ductal adenocarcinoma (DAC) is the most common variant histological subtype of prostate carcinoma, which has a unique and aggressive biology. In contrast to prostatic acinar adenocarcinoma (PAC), the majority of DACs present with lower urinary tract symptoms, have a low serum PSA and are often cl...
Prostate cancer is one of the more heterogeneous tumour types. In recent years, with the rapid development of single-cell sequencing and spatial transcriptome technologies, researchers have gained a more intuitive and comprehensive understanding of the h
Prostate cancer is one of the more heterogeneous tumour types. In recent years, with the rapid development of single-cell sequencing and spatial transcriptome technologies, researchers have gained a more intuitive and comprehensive understanding of the h
Prostate canceris one of the most frequently diagnosed cancers in men. Significant advances have been made in tumor biology, the diagnosis, histological and immunohistochemical characterization, molecular phenotype, and treatment of primary and metastaticprostate cancer. However, many challenges remain in ...
or omniclonal or prepared by molecular biology techniques. The term “antibody”, as used herein and throughout the instant specification is also meant to include aptamers and single-stranded oligonucleotides such as those derived from an in vitro evolution protocol referred to as SELEX and well kn...
Prostate gland volume was also predictive of bNED failure in the favorable but not the unfavorable group.doi:10.1016/S0360-3016(01)02764-XJoseph M KaminskiAlexandra L HanlonEric M HorwitzWayne H PinoverRaj K MitraGerald E HanksInternational Journal of Radiation Oncology Biology Physics...