Exosome uptake by the prEC cells was confirmed using FACS analysis, showing that PC3exosomes were internalized much more than the LNCaP exosomes. 3. Bijnsdorp, IV, et al. (2013)"Exosomal ITGA3 interferes with non-cancerous prostate cell functions and isA Maxwell...
is a common condition in older adults. BPH develops because the number of prostate cells increases (hyperplasia) or the cells get bigger (hypertrophy). The prostate wraps around the urethra. An enlarged prostate can press on the urethra. This may cause problems with storing urine or emptying ...
In subject area: Medicine and Dentistry PC-3 cells are a human metastatic prostate cancer cell line, established in 1979 from a bone metastasis in a 62-year-old Caucasian male. From: Principles of Gender-Specific Medicine (Fourth Edition), 2023 ...
The prostate gland contains a simple columnar epithelium with three differentiated cell types – basal, luminal, and neuroendocrine cells – that are embedded in a fibro-muscular stroma (Isaacs et al., 1981; Wang et al., 2001). The major epithelial cell population is luminal secretory cells whi...
Cancer-associated fibroblasts (CAFs) are the major components of TME stroma and have an important role in tumorigenesis, proliferation, progression and invasion18,19,20,21,22. CAFs are mainly transformed by intrinsic fibroblasts or stellate cells in tissues stimulated by growth factors. In addition,...
Extracellular vesicles (EVs) are natural nanoparticles secreted by cells in the body and released into the extracellular environment. They are associated with various physiological or pathological processes, and considered as carriers in intercellular information transmission, so that EVs can be used as ...
16 Exosomes are small, double-lipid membrane vesicles that are secreted from cells. Exosomes encapsulate a portion of the parent cell cytoplasm and are shed into various biofluids, including blood and urine. They are a rich source of cellular protein and RNA, and are promising for profiling RNA...
so it is used to treat more advanced cancer and cancer that did not respond to hormone therapy. Treatment is usually intravenous and is given in cycles lasting 3-6 months. Because the chemotherapy kills other fast-growing cells in the body, you may have hair loss and mouth sores. Other si...
3). For the combined data set, large aggregates of bacteria in urine were also significantly associated with increased prostate cancer risk (p = 0.006; Supplementary Fig. 2). The bacteria also appeared, in some cases, to be intracellular within human cells (Supplementary Fig. 4). Table 1....
In addition, a significant subpopulation of VCaP cells appears to have lost the Y chromosome, although this was not reported in the comprehensive SKY analyses of prostate cancer cell lines.63,106 An androgen-independent subline of VCaP has also been generated by subcutaneous propagation of VCaP ...