Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using ...
For this population-based study, men in the UK living 18-42 months after diagnosis of prostate cancer were identified through cancer registration data. A postal survey was administered, which contained validated measures to assess functional outcomes (urinary incontinence, urinary irritation and ...
Advanced prostate and bladder cancer are two outstanding unmet medical needs for urological oncologists. The high prevalence of these tumours, lack of effective biomarkers and limited effective treatment options highlight the importance of basic research in these diseases. Galectins are a family of β...
UK guidelines on F-18-fluciclovine PET/CT in prostate cancer imaging The purpose of these guidelines is to assist specialists in Nuclear Medicine and Radionuclide Radiology in recommending, performing, interpreting and repor... A Afaq,F Gleeson,A Scarsbrook,... - 《Nuclear Medicine Communications...
My journey with Prostate Cancer UK has since continued, and I ran the London Marathon for them in April 2016, bringing our combined total donations to £21,000. Unfortunately I’m a terrible swimmer, so the triathlon is not on the cards… A very generous welcome at the PC UK offices ...
Flow of Participants in the Comparative Effectiveness Analyses of Surgery and Radiation (CEASAR) Study of the Association Between Contemporary Treatments for Localized Prostate Cancer Through 5 Years View LargeDownload Figure 2. Unadjusted Disease-Specific Function for Men With Favorable-Risk Disease in a...
Prostate cancer is characterized by considerable geo-ethnic disparity. African ancestry is a significant risk factor, with mortality rates across sub-Saharan Africa of 2.7-fold higher than global averages1. The contributing genetic and non-genetic factor
This secondary analysis of the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial estimates the long-term risk of any prostate cancer
Prostate cancer (PC) represents a global health issue. Treatment for locally advanced and metastatic PC remains unsatisfactory. The androgen receptor (AR) has been validated in having a key role in both naïve and castrate-resistant PC (CRPC). However, the significance of other signalling pathwa...
Cancer immunotherapies such as bispecific T-cell engagers have seen limited adoption in prostate cancer (PC), possibly due to differing levels of cancer receptor expression and effector T-cell infiltration between patients and inherent defects in T-cell engager design. Methods CD8+ T-cell infiltration...