A method for treating prostate cancer, including advanced prostate cancer, in a subject in need thereof is at least 80 mg N- (4- (1- (2,6-difluorobenzyl) -5. -((Dimethylamino) methyl) -3- (6-methoxy-3-pyridazinyl) -2,4-dioxo-1,2,3,4-tetrahydrothieno [2,3-d] pyrimidin-6-yl...
Clinical practice guidelines from different organizations on treatment of localized prostate cancer are of variable quality and fall short of current stand... JL Mohler,RR Bahnson,B Boston,... - 《Journal of the National Comprehensive Cancer Network Jnccn》 被引量: 1492发表: 2010年 Prostate Cance...
Currently, most prostate cancer treatment guidelines worldwide recommend an observation-based approach, primarily active surveillance, for such cases, resembling a treatment model for precancerous conditions rather than curative treatment for the majority of cancers26,27. In the 12 cases with a PI-...
Nearly one-third of patients with prostate cancer (PCa) experience biochemical recurrence (BCR) after primary definitive treatment. BCR increases the risk of distant metastasis and mortality in patients with prognostically unfavorable features. These patients are best managed with a tailored treatment str...
NCCN guidelines updates: management of prostate cancer. J Natl Compr Canc Netw. 2019;17(5.5):583-586.PubMedGoogle Scholar 25. Hugosson J, Roobol MJ, Månsson M, et al; ERSPC Investigators. A 16-yr follow-up of the European Randomized Study of Screening for Prostate Cancer. Eur ...
African American men, compared with non-Hispanic White men, had a statistically significant increased 10-year cumulative incidence of disease progression (59.9% vs 48.3%) and definitive treatment (54.8% vs 41.4%), but not metastasis (1.5% vs 1.4%) or prostate cancer–specific mortality (1.1% ...
Structures resembling large oncosomes were identified in the circulation of different mouse models of prostate cancer, and their abundance correlated with tumor progression. Similar large vesicles were also identified in human tumor tissues, but they were not detected in the benign compartment. They ...
Impact of diagnosis and treatment of clinically localized prostate cancer on health-related quality of life for older Americans: a population-based study Cancer, 118 (2012), pp. 5679-5687 CrossrefView in ScopusGoogle Scholar [17] NCCN. Clinical practice guidelines in oncology: prostate cancer; ve...
2 This underscores the need for developing treatment approaches that not only effectively control disease progression but also enhance or maintain patient-reported outcomes (PROs) in this population. The androgen receptor axis is crucial in prostate cancer pathology by driving tumor proliferation and ...
Genetic testing, to identify pathogenic or likely pathogenic variants in prostate cancer, is valuable in guiding treatment decisions for men with prostate cancer and to inform cancer prevention and early detection options for their immediate blood relatives. There are various guidelines and consensus stat...