Prostate cancer index (cancer volume / prostate volume) (PCindex) may also play a role in prognosis. The objective of this study is to determine whether PCindex is a stronger predictive factor than cancer volume for adverse final histopathology (positive section margins, positive lymph nodes, ...
Prostate cancer is a multifactorial disease influenced by various molecular features. Over the past decades, epigenetics, which is the study of changes in gene expression without altering the DNA sequence, has been recognized as a major driver of this disease. In the past 50 years, advancements i...
The National Comprehensive Cancer Network (NCCN, v.2.2018) recommends baseline screening beginning at age 45. "African-American men and men with a family history of prostate cancer represent high-risk groups. However, the panel believes that current data are insufficient to definitively inform the b...
b. The European Association of Nuclear Medicine (EANM) proposed a “miTNM” (molecular imaging TNM) classification based on PSMA PET/CT results. The prognosis of miT, miN, and miM stages may be better than that of T, N, and M stages, but the extent of this prognostic change and its ...
The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance is unknown. Here, we identify that the SNP variant-induced change in PSA biochemical...
Reliable prognostic biomarkers to distinguish indolent from aggressive prostate cancer (PCa) are lacking. Many studies investigated microRNAs (miRs) as PCa prognostic biomarkers, often reporting inconsistent findings. We present a systematic review of th
Smoking and aggressive prostate cancer: a review of the epidemiologic evidence. Cancer Causes Control. 2009;20(10):1799-181019562492PubMedGoogle ScholarCrossref 3. Daniell HW. A worse prognosis for smokers with prostate cancer. J Urol. 1995;154(1):153-1577776411PubMedGoogle ScholarCrossref 4...
The natural history of prostate carcinoma based on a Danish population treated with no intent to cure. Cancer.1997;80:917-928.http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?db=m&form=6&Dopt=r&uid=entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9307192&dopt=AbstractGoogle ...
Statins and prostate cancer—hype or hope? The biological perspective Article 29 June 2022 Prostate cancer prognosis after initiation of androgen deprivation therapy among statin users. A population-based cohort study Article Open access 31 March 2021 Statin use and outcomes of oncological treatmen...
Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent in the treatment of this malignant disease. Macroautophagy/autophagy is