In the complex tumor microenvironment (TME), mesenchymal cells are key players, yet their specific roles in prostate cancer (PCa) progression remain to be fully deciphered. This study employs single-cell RNA sequencing to delineate molecular changes in tumor stroma that influence PCa progression and...
We sought to develop a platform to interrogate prostate cancer drivers rapidly and comprehensively at larger scale compared to traditional genetically engineered mouse models (GEMMs), focusing on the need to dynamically model the PRAD-to-NEPC transition. Using multiplexed editing and lentiviral oncogene ...
2. Unfortunately, resistance to ADT invariably arises and the tumour relapses as aggressive, castration-resistant prostate cancer (CRPC)3; a significant clinical challenge due to a lack of therapeutic targets
and#8226 The nature of prostate cancerand#8226 Testing proceduresand#8226 Treatment choices, including prostatectomy, hormonal manipulation, radiation seeding, cryosurgery, and moreand#8226 Diet, vaccines, homepathic, and experimental treatmentsand#8226 Sexual activity and side effects --what to expect...
Bone metastasis (BM) is a common and fatal condition in patients with castration-resistant prostate cancer (CRPC). However, there are no useful blood biomarkers for CRPC with BM, and the mechanism underlying BM is unclear. In this study, we investigated precise blood biomarkers for evaluating ...
3a). The cancer cell populations present in the left apical region of the prostate migrated to the two positive left pelvic lymph nodes, and at least once, spread occurred from the right apex to the right pelvic lymph node (Fig. 6a). The dominant population in the left side LNs (Bb1,...
Prostate cancer is the second most frequent cancer diagnosed in men worldwide. Localized disease can be successfully treated, but advanced cases are more problematic. After initial effectiveness of androgen deprivation therapy, resistance quickly occurs.
Prostate cancer (PCa) is the second most common cancer in male and usually treated by radiation therapy combined with drugs, or by surgery[1]. The development of PCa is induced by many factors, such as age, genetics, geographic location, and ethnic inheritance. Prostatic inflammation is one ...
Nowadays, prostate cancer is the most widespread tumour in worldwide male population. Actually, brachytherapy is the most advanced radiotherapy strategy for the local treatment of prostate cancer. It consists in the placing of radioactive sources closed
Prostate cancer (PCa) remains one of the most prevalent male cancers in the United States, with over an estimated 26,000 cancer deaths annually1,2. Presently, androgen deprivation therapy (ADT) with antiandrogens to suppress androgen synthesis or prevent androgens from binding to the androgen rece...