Prostate cancer (PCa) shows strong dependence on the androgen receptor (AR) pathway. Here, we show that squalene epoxidase (SQLE), an enzyme of the cholesterol biosynthesis pathway, is overexpressed in advanced PCa and its expression correlates with poor survival. SQLE expression is controlled by...
clonal evolution that has enabled both 'metastasis-to-primary' and 'metastasis-to-metastasis' re-seeding *Correspondence: T Mitchell; E-mail: tommitchell@doctors.org.uk Received 13 April 2015; revised 16 May 2015; accepted 20 May 2015; published online 30 June 2015 & 2015 Cancer Research UK...
The authors of the highly respected Choices offer invaluable detailed information about: and#8226 The nature of prostate cancerand#8226 Testing proceduresand#8226 Treatment choices, including prostatectomy, hormonal manipulation, radiation seeding, cryosurgery, and moreand#8226 Diet, vaccines, homepathic,...
3a). The cancer cell populations present in the left apical region of the prostate migrated to the two positive left pelvic lymph nodes, and at least once, spread occurred from the right apex to the right pelvic lymph node (Fig. 6a). The dominant population in the left side LNs (Bb1,...
the physiologic significance of the high levels of PAP and their function are not well understood (Chu et al., 1977;Lowe and Trauzzi, 1993). Serum acid phosphatase concentration was once widely measured as biomarker for metastatic prostate cancer; however, this has been usurped the more sensitive...
Newly growing evidence highlights the essential role that epitranscriptomic marks play in the development of many cancers; however, little is known about the role and implications of altered epitranscriptome deposition in prostate cancer. Here, we show t
Cancer cell metabolism requires sustained pools of intracellular nicotinamide adenine dinucleotide (NAD+) which is maintained by a balance of NAD+ hydrolase activity and NAD+ salvage activity. We recently reported that human prostate cancer can be initia
Bone metastasis (BM) is a common and fatal condition in patients with castration-resistant prostate cancer (CRPC). However, there are no useful blood biomarkers for CRPC with BM, and the mechanism underlying BM is unclear. In this study, we investigated precise blood biomarkers for evaluating ...
In the complex tumor microenvironment (TME), mesenchymal cells are key players, yet their specific roles in prostate cancer (PCa) progression remain to be fully deciphered. This study employs single-cell RNA sequencing to delineate molecular changes in t
USA and 3Department of Oncology and Laboratory Medicine, Yamaguchi University Graduate School of Medicine, Ube, Japan Background: The purpose of this study was to identify prostate cancer (PC) oncogenic microRNAs (miRs) based on miR microarray and to investigate whether these oncogenic miRs may be...