Prostate cancer is one of the most common cancers that affect men, especially those > 50 years of age. Typically, prostate cancer has an indolent course and is usually discovered while still locali...
Home to the journal Oncology, Cancer Network provides research and opinion on the screening, early detection, diagnosis, treatment, and prevention of cancers.
Once the diagnosis is confirmed, the next step is staging the disease. Most commonly, Gleason score is used to determine your disease stage. It ranges from 2 (nonaggressive cancer) to 10 (aggressive cancer). Cancer with higher Gleason score tends to spread more quickly. In some cases, your...
Prostate cancer (PC) is an epithelial malignancy occurring in the prostate. PC ranks second in incidence among all male malignancies globally by the latest statistics from the World Health Organization. Notably, China has seen a more rapid increase in PC incidence compared to developed European and...
Cancer staging is typically the most important predictor of survival, and often dictates the cancer treatment options that need to be considered. TheTNM staging systemis widely used to stageprostate cancerusing a combination ofDRE,PSAtesting,prostate biopsyfindings, and imaging studies (according to ...
Especially in cases of PI-RADS 3/4 lesions, the diagnosis of prostate cancer remains ambiguous, and current guidelines recommend that these lesions should undergo biopsy6. Nevertheless, research indicates that the positive biopsy rate for PI-RADS 3 lesions ranges from 0.0 to 24.7%, while for PI...
High-grade prostate cancerRiskObjectives To assess the applicability of the Prostate Cancer Prevention Trial High Grade (Gleason grade≥7) Risk Calculator (PCPTHG) in ten international cohorts, representing a range of populations. Methods A total of 25,512 biopsies from 10 cohorts (6 European, 1...
6-9 Low percentages of free PSA are well established as indicators of prostate cancer,10-16 but the selection of cutoffs for use in clinical practice is complicated by the partial dependence of percentage of free PSA on patient age, prostate size, and the total PSA level.10-12,16,17 In...
cancer cases in men, with one in 125 men at risk of being diagnosed with PC [5]. The higher incidence rate of PC in the last few decades has been mainly due to increased prostate-specific antigen (PSA) screening, leading to a decrease in mortality among diagnosed cases [6,7,8,9,10...
Dr Egawa is on our Editorial Board and we recognize the many contributions he is making in the prostate cancer field. On the basic science front, there are interesting articles on MMP and TIMP expression (Brehmer et al), gene therapy and lentiviral vectors (Bastide et al), HK-6, 10, ...