Once tumor cells metastasize to the bone, the prognosis for prostate cancer patients is generally very poor. The mechanisms involved in bone metastasis, however, remain elusive, because of lack of relevant animal models.Charles Richardson
In the current study, we aimed to identify risk factors associated with cancer prognosis and to detect the bone metastasis pattern of PCa patients in SEER database and a Chinese hospital. We compared the consistency and difference between SEER data and local hospital data. We were particularly in...
Osteoblasts in prostate cancer metastasis to bone Metastasis to bone is common in lung, kidney, breast and prostate cancers. However, prostate cancer is unique in that bone is often the only clinically det... CJ Logothetis,SH Lin - 《Nature Reviews Cancer》 被引量: 839发表: 2005年 Use of...
LLNL scientists Gaby Loots (left) and Aimy Sebastian count live cells for their research tying a specific protein that has been found to inhibit prostate cancer metastasis to bone. Credit: Julie Russell/LLNL. Scientists from Lawrence Livermore National Laboratory...
of Prostate Cancer Site of Bone Metastasis Useful for Prognosis of Prostate CancerSite of Bone Metastasis Useful for Prognosis of Prostate CancerAdministrator
emission tomography have been utilized to detect bone metastases at an early stage. In addition, metastasis-directed therapy, such as stereotactic body radiation therapy, has been attempted. In the future, patients with bone metastatic prostate cancer will be divided into subgroups and their treatment...
Bone histology at autopsy and matched bone scintigraphy findings in patients with hormone refractory prostate cancer: The effect of bisphosphonate therapy ... Bisphosphonates (BisP) are non-metabolized compounds with high bone affinity used in bone metastasis diagnosis and treatment. Currently, BisP are...
Reliable prognostic biomarkers to distinguish indolent from aggressive prostate cancer (PCa) are lacking. Many studies investigated microRNAs (miRs) as PCa prognostic biomarkers, often reporting inconsistent findings. We present a systematic review of th
Clinically, prostate cancer (PCa) exhibits a high avidity to metastasize to bone. Myc-associated zinc-finger protein (MAZ) is a well-documented oncogene involved in the progression and metastasis of multiple cancer types, even in PCa. However, the clinical significance and biological roles of MAZ...
to affect the viability of osteoblasts, a major cell type affected in PCa bone metastasis, we choose to determine the role of the EV cargo. As other studies have identified some protein components of cancer EV cargos, we choose to ascertain the potential contribution of the RNA cargo of PCa...