On multivariable analysis, after adjusting for serum PSA level (10 or less or more than 10 ng/mL) and pathologic stage, Gleason score (6 or less, 7, 8 or more) remained a statistically significant predictor of DFS (P = 0.0001). Conclusions. Patients with Gleason score 7 prostate cancer ...
Gleason score 7, in different proportions of grades 3 and 4, is the score most frequently assigned to prostate cancer in our radical prostatectomy specimens (RPSs). We correlated the major grade component of score 7 tumors with clinicopathologic parameters and disease-free survival. Methods. All ...
On multivariable analysis, after adjusting for serum PSA level (10 or less or more than 10 ng/mL) and pathologic stage, Gleason score (6 or less, 7, 8 or more) remained a statistically significant predictor of DFS (P = 0.0001). CONCLUSIONS: Patients with Gleason score 7 prostate cancer ...
Prostate cancer overexpresses CD44 variants 7-9 at the messenger RNA and protein level. 来自 国家科技图书文献中心 喜欢 0 阅读量: 31 作者:KA Iczkowski,B Shan,CG Pantazis 摘要: BACKGROUND: In prostate cancer, prior data show down-regulated immunohistochemical expression of cell adhesion protein ...
6,7 Multiparametric, contrast-enhanced magnetic resonance imaging (MRI) is a diagnostic test with good accuracy for detection of clinically significant cancer in men referred to the hospital with an elevated PSA level.8-10 Recently, biparametric, noncontrast (short) MRI protocols have been ...
Androgen receptor splice variant 7 (AR-V7), a form of ligand-independent and constitutively activating variant of androgen receptor (AR), is considered as the key driver to initiate castration-resistant prostate cancer (CRPC). Because AR-V7 lacks ligand-
Our work reveals that the hormone-independent AR splice variant 7 (ARv7) contributes to this process by repressing the transcription of genes with tumor-suppressive activity. Thus, targeting ARv7 may improve currently available prostate cancer therapies by restoring expression of these genes that can...
WebMD's slideshow covers prostate cancer: who's at risk, symptoms, tests, staging, treatments, survival, and foods that may help lower your risk for prostate cancer.
Prostate cancer is a major cause of cancer morbidity and mortality. Intra-prostatic inflammation is a risk factor for prostate carcinogenesis, with diet, chemical injury and an altered microbiome being causally implicated. Intra-prostatic inflammatory ce
Prostate cancer is a commonly diagnosed cancer in men and a leading cause of cancer deaths. Whilst the underlying mechanisms leading to prostate cancer are still to be determined, it is evident that both genetic and epigenetic changes contribute to the d