In 1936 prostatic acid phosphatase (PAP) became the key serum marker for monitoring prostate cancer (PCa) treatment (1–3). Approximately 50 yr later, prostate-specific antigen (PSA) emerged as the most useful serum marker for PCa management followed a f
These are important markers for disease, explains Parker. Anions such as citrate and lactate are formed in cell metabolism processes which alter when cancers grow - citrate levels in prostate fluid fall as prostate cancer progresses.Katherine Davies...
Understanding the intricacies of lethal prostate cancer poses specific challenges due to difficulties in accurate modeling of metastasis in vivo. Here we show that NPKEYFP mice (for Nkx3.1CreERT2/+; Ptenflox/flox; KrasLSL-G12D/+; R26R-CAG-LSL-EYFP/+) develop prostate cancer with a high ...
4662 had RPKM values greater than one, and 116 transcripts (110 genes) were significantly up- or downregulated in PCa (Table1). Known PCa markers were upregulated in PCa urine (Supplementary Table2), and differentially expressed genes were enriched for a number of important cancer pathways...
It's possible to have different types of cancer in your prostate. Your lab report will tell your doctor where the pathologist found cancer cells, how much of each tissue sample contains cancer cells, and your Gleason score. Why Is the Gleason Score Important? Your Gleason score is an importa...
structure-based design, synthesis and testing of non-peptide, cell-permeable, potent small molecule smac mimetics as a new therapy for prostate cancer. revision 热度: Genetic variants in metabolizing genes NQO1, NQO2, MTHFR and risk of prostate cancer a study from North India ...
Circulating microRNAs as stable blood-based markers for cancer detection Proc Natl Acad Sci USA, 105 (2008), pp. 10513-10518 CrossrefView in ScopusGoogle Scholar [10] J.C. Brase, M. Johannes, T. Schlomm, M. Fälth, A. Haese, T. Steuber, et al. Circulating miRNAs are correlated wi...
circular RNA prostate cancer function ceRNA clinical significance Introduction Prostate cancer (PCa) is the most common type of cancer and the second leading cause of cancer mortality in men.1 In recent years, the incidence of PCa has significantly increased around the world, which seriously menace...
An individualised risk-stratified screening for prostate cancer (PCa) would select the patients who will benefit from further investigations as well as therapy. Current detection methods suffer from low sensitivity and specificity, especially for separat
Both genes have been previously identified as strong prostate cancer markers [27, 28] and both are in the top 40 most abundant genes in our EST library (data not shown). This would seem to indicate that our approach is capable of identifying genes important to prostate cancer pathology. ...