These are important markers for disease, explains Parker. Anions such as citrate and lactate are formed in cell metabolism processes which alter when cancers grow - citrate levels in prostate fluid fall as prostate cancer progresses.Katherine Davies...
Prostate cancer (PCa) is the most prevalent cancer in males in Western countries. In Europe, an incidence of 450,000 new cases and a mortality of 107,000 cancer deaths per year have been estimated for 2018 [1]. Prostate-specific antigen (PSA) remains as the most used biomarker in the d...
Prostate cancer is the second most common malignancy in men worldwide and consists of a mixture of tumor and non-tumor cell types. To characterize the prostate cancer tumor microenvironment, we perform single-cell RNA-sequencing on prostate biopsies, prostatectomy specimens, and patient-derived organo...
We previously reported that the ADT-activated transcription factor, ZBTB46, is associated with drug resistance and metastasis of prostate cancer23. As to relationships among ZBTB46, AR signaling, and NEPC progression, we checked expression levels of ZBTB46, neuroendocrine markers (chromogranin A/B (...
The prostate gland is the most common site of cancer and the second leading cause of cancer death in American men. Recent emerging molecular biological technologies help us to know that epigenetic alterations such as DNA methylation within the regulatory
Most patients with prostate cancer inevitably progress to castration-resistant prostate cancer (CRPC), at which stage chemotherapeutics like docetaxel become the first-line treatment. However, chemotherapy resistance typically develops after an initial p
techniques to process prostate cancer specimens either(macrodissection) or using laser capture microdissection are presented in detail along with extensive technical notes. Although we focus on prostate cancer and discuss the specific methods utilized in our lab, the processes discussed are generalizable ...
2. Genetic Predisposition for Prostate Cancer 2.1. Genetic Markers of PC The vast majority of PC cases are sporadic and caused by turning off tumor suppressor genes and turning on oncogenes, and only 5–10% of PC cases have family history, being caused by germline mutations [10]. The prese...
Prostate cancer remains one of the leading causes of cancer death in men worldwide. In the past decade, several new treatments for advanced prostate cancer have been approved. With a wide variety of available drugs, including cytotoxic agents, androgen receptor axis-targeted therapies, and alpha-...
This is one of the most long-term and comprehensive molecular studies of prostate cancer progression. The slow progression of the disease makes studying its biology difficult. The bank of biopsies maintained for the last 20 years at Garvan and St Vincent's Hospital, allowed the researchers to an...