DENOSUMAB slows the spread of prostate cancer to bones in men at risk of disease progression, according to a Lancet study published online this week (16 November 2011). An international team of researchers looked at whether denosumab, a human monoclonal antibody that inhibits osteoclast formation, ...
A brief overview of bone-metastatic migration in advanced prostate cancer and how it impacts survival. CAN WE BE DOING MORE TO CONFRONT THE DEADLY THREAT OF PROSTATE CANCER IN THE BONE? Learn more about the fight against mCRPC in the bones CONTACT A BAYER REPRESENTATIVE mCRPC=Metastatic Castr...
the spread of the prostate cancer to the bones (bone metastases) cancause severe pain and fracture, and hormonal therapy for prostate cancer can cause bone loss, fracture, and joint pain.
Prostate cancer cells-osteoblast interaction shifts expression of growth/survival-related genes in prostate cancer and reduces expression of osteoprotegeri... Navone, Prostate cancer cells-osteoblast interaction shifts expression of growth/survival-related genes in prostate cancer and reduces expression of ...
Key words : bone metastasis, cancer therapy, micrometastasis, prostate cancer, survival factors Plan Systematic spread of the tumour cells: the dynamic journey to the bones Colonizing the bone: the orchestration of an osteoclastic bone resorption Sheltering inside the bone marrow: domination of the ...
prostate cancer has spread beyond the prostate and nearby structures, survival rates fall. "Distant" prostate cancer has moved into farther-away areas of the body, such as the bones, liver, or lungs. Among those with distant prostate cancer, about one-third will survive for 5 years after ...
prostate cancer cells into the bone and to provide a better understanding of the basis of cancer cell survival within the bone microenvironment. The development of animal models that recapitulate more closely the human clinical scenario of prostate cancer will greatly benefit the generation of better ...
If the cancer has spread to remote organs (metastasis) symptoms may includefatigue, malaise, andweight loss. Metastasis to the bones can cause deep bone pain, particularly in the hips and back or even bone fractures from weakening of the bone. ...
Extent of the disease, Gleason score of 8 to 10 and presence of bone pain are other important prognostic factors in metastatic prostate cancer. The median progression-free survival in patients with minimal disease (metastatic disease confined to pelvis, spine or nodes) is about 2 years and in ...
1 Depending on the pathological stage, histological grading, and serum PSA levels, over 50% of cases of locally advanced cancer progress against the background of treatment. Most often, distant metastases are found in the bones. About 6% of cases are at an advanced stage at the time of ...