Due to the high expression of prostate-specific membrane antigen (PSMA) on the cell membrane of PC cells, this protein represents an attractive molecular target for targeted delivery to prostate cancer [8]. PSMA protease was discovered in 1987 [9] and was first cloned in 1993 [10]. This tr...
Prostate cancer, disease characterized by uncontrolled growth of cells within the prostate gland. Prostate cancer is a frequently diagnosed cancer among males. Learn more about the causes, symptoms, and treatment of prostate cancer.
Patients with prostate cancer are at increased risk of bone-related complications due to the phenomena of metastatic spread to bone and osteoporosis, worsened by exposure to hormonal therapies.doi:10.1002/tre.853Gordon AndersonJoe O'SullivanJohn Wiley & Sons, IncTrends in Urology and Men s Health...
What causes prostate cancer is a subject of intensive research. It is likely that prostate cancer occurs due to many reasons. Predominately a disease of elderly men, the diagnosis of prostate cancer is rare before age 40 but increases dramatically thereafter. What are the risk factors for prosta...
While there's no way to pinpoint the exact causes of prostate cancer, there are many things that increase your risk. Some people are more likely to get prostate cancer than others based on one or more gene variants they were born with. Lifestyle and other factors also play some role. So...
Prostate cancer is usually a very slow-growing cancer, often causing no symptoms until it is in an advanced stage. Most men with prostate cancer die of other causes and many never know that they have the disease. But once prostate cancer begins to grow quickly or spreads outside the prostat...
S1B, C). These analyses indicate that high c-Myc expression in PrCa patients might be more likely due to the deubiquitination process. Fig. 1: Overexpression of c-Myc in prostate cancer is due to both transcriptional and posttranslational regulation. A MYC is amplified in PrCa patients in ...
What causes prostate cancer? Cancer is the uncontrollable growth of cells. It occurs when a mutation or abnormal change occurs that upsets how our cells multiply and divide. This allows the cell to keep dividing, out-of-control, instead of dying and being replaced by a new cell. Sometimes ...
Prostate cancer is usually a very slow-growing cancer, often causing no symptoms until it is in an advanced stage. Most men with prostate cancer die of other causes and many never know that they have the disease. But once prostate cancer begins to grow quickly or spreads outside the prostat...
(PIN). The earliest accepted stage in prostate carcinogenesis, with phenotypic, biochemical and genetic changes due to incipient cancer but without invasion of the basement membrane of acini. Peri-prostatic adipose tissue (PPAT). Fat deposits that surround the prostate gland (which can be present ...