Patients with prostate cancer are at increased risk of bone-related complications due to the phenomena of metastatic spread to bone and osteoporosis, worsened by exposure to hormonal therapies.doi:10.1002/tre.853Gordon AndersonJoe O'SullivanJohn Wiley & Sons, IncTrends in Urology and Men s Health...
Due to the high expression of prostate-specific membrane antigen (PSMA) on the cell membrane of PC cells, this protein represents an attractive molecular target for targeted delivery to prostate cancer [8]. PSMA protease was discovered in 1987 [9] and was first cloned in 1993 [10]. This tr...
For f a Mann-Whitney U test was used due to the non-normal data distribution observed. The box plot includes 25th to 75th of all IL-8 positive cells/mm2 values with horizontal line indicating the median values. The whiskers represent the highest values, including outliers and extremes. ...
(PIN). The earliest accepted stage in prostate carcinogenesis, with phenotypic, biochemical and genetic changes due to incipient cancer but without invasion of the basement membrane of acini. Peri-prostatic adipose tissue (PPAT). Fat deposits that surround the prostate gland (which can be present ...
Prostate cancer is usually a very slow-growing cancer, often causing no symptoms until it is in an advanced stage. Most men with prostate cancer die of other causes and many never know that they have the disease. But once prostate cancer begins to grow quickly or spreads outside the prostat...
What causes prostate cancer is a subject of intensive research. It is likely that prostate cancer occurs due to many reasons. Predominately a disease of elderly men, the diagnosis of prostate cancer is rare before age 40 but increases dramatically thereafter. ...
What causes prostate cancer? Cancer is the uncontrollable growth of cells. It occurs when a mutation or abnormal change occurs that upsets how our cells multiply and divide. This allows the cell to keep dividing, out-of-control, instead of dying and being replaced by a new cell. Sometimes ...
Prostate cancer, disease characterized by uncontrolled growth of cells within the prostate gland. Prostate cancer is a frequently diagnosed cancer among males. Learn more about the causes, symptoms, and treatment of prostate cancer.
Like all cancers, prostate cancer begins when a mass of cells has grown out of control and begins invading other tissues. Cells become cancerous due to the accumulation of defects, or mutations, in their DNA. Most of the time, cells are able to detect and repair DNA damage. If a cell ...
While there's no way to pinpoint the exact causes of prostate cancer, there are many things that increase your risk. Some people are more likely to get prostate cancer than others based on one or more gene variants they were born with. Lifestyle and other factors also play some role. So...