colorectal cancerdisease-free survivaloverall survivalprogression-free survivalsurrogate endpointsDespite significant advances in the treatment of hematological malignancies over the previous decades, morbidity and mortality from theses disorders still remain high. New discoveries in the pathways involved in the ...
Advanced prostate and bladder cancer are two outstanding unmet medical needs for urological oncologists. The high prevalence of these tumours, lack of effective biomarkers and limited effective treatment options highlight the importance of basic research in these diseases. Galectins are a family of β...
while to-date, somatic mutations are not shown to be [6,25]. Patients with germlineBRCA2pathogenic variants have a 20-fold risk of death related to prostate cancer [26].ATM,a DNA-damage sensor gene, is frequently altered in mCRPC. While a complete inactivation ofBRCA2,BRCA1andPALB2imprin...
Castration-resistant prostate cancer (CRPC) is associated with a poor prognosis and poses considerable therapeutic challenges. Recent genetic and technological advances have provided insights into prostate cancer biology and have enabled the identification of novel drug targets and potent molecularly targeted...
Part or all of your prostate may be removed. You may also need to have some lymph nodes taken out. This may help keep the cancer from spreading to other parts of your body. Your healthcare provider may recommend a combination of radiation therapy and surgery....
The study, published on Wednesday, revealed that a single glass of beer or wine every two weeks can increase a man's chance of developing the cancer by up to 10 percent. Tanya Chikritzhs, leader of the alcohol policy team at the Curtin University, said that the research should prompt hea...
Red wine, liquor, and beer were not associated with prostate cancer nor was total alcohol consumed at ages 18, 30, and 45. Associations of alcohol use with prostate cancer are modest and complex. More detailed assessment of specific alcoholic beverages is warranted in future studies. 展开 ...
E Giovannucci - 《Cancer Causes Control》 被引量: 1893发表: 2005年 Is vitamin D deficiency a risk factor for prostate cancer? (Hypothesis). This hypothesis is consistent with known antitumor properties of Vitamin D, and may suggest new avenues for research in prostate cancer... G Schwartz,B...
Recent US Food and Drug Administration (FDA) approval of the prostate cancer vaccine known as sipuleucel-T (Provenge; Dendreon Inc) marks the first antigen-specific immunotherapy approved for the treatment of cancer. Several other antigen-specific immunotherapy approaches are under development for cancer...
Advanced prostate cancer remains one of the most common and deadly cancers, despite advances in treatment options. Immunotherapy has provided little benefit to a majority of patients, largely due to the immunosuppressive tumor microenvironment that gives rise to inherently “cold tumors”. In this revi...