Bone Metastases from Prostate Cancer: From Symptom Control to Pain PalliationProstate cancer is the second most frequently diagnosed cancer and the fifth leading cause of cancer-related death in men. The majority, around 90 %, of patients with metastatic castration-resistant prostate cancer (mCRPC)...
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If the patient does screening tests for prostate cancer, it will only be possible to discover prostate cancer when there are symptoms of metastases. The most common ones are bone pain. All patients with prostate changes symptoms should consult a doctor. The PSA associated with the digital recta...
Bone metastasis is a common problem for prostate cancer patients and it reduces not only their quality of life but also their chance of survival. On the other hand, with regard to the frequency of bone metastasis for each patient enrolled in a clinical trial using a new CRPC (castration-res...
The current clinical practice for treating bone metastases is systemic chemotherapy or hormonal therapy and bisphosphonates. U.S. It also defines palliative care as treatment that alleviates the symptoms of cancer... Janjan,Nora,Lutz,... - 《Journal of Palliative Medicine》 被引量: 133发表: 2009...
This enhanced antioxidant capacity seems to be an adaptation of cells to respond to changes in oxidative levels and also reflects the importance of ferroptosis in PCa bone metastases. The high metabolic activity of cancer cells makes it necessary to synthesize more GSH to prevent oxidative stress, ...
screening has yet to demonstrate a survival benefit. While PSA can diagnose prostate cancer earlier than symptoms, physical exam, or other blood chemistries, it remains limited as a predictive marker and provides little insight as to the specific biology of an individual's prostate cancer. The ...
Patients with prostate cancer tend to die from bone metastases. Until now, no evidence has shown that Paget's disease of bone (PDB) affects the progression... SM Tu,A Som,B Tu,... - 《British Journal of Cancer》 被引量: 14发表: 2012年 Zoledronic acid has long-term efficacy in reduc...
There was also no correlation with lymph node metastases. Furthermore, there was no interdependency between the preoperatively detected number of cells and the established risk factors.We assume the presence of epithelial cells in bone marrow to be an independent parameter, the clinical importance of...
Men with advanced disease typically undergo androgen deprivation therapy via medical castration that initially reduces tumor burden and symptoms, but castrate-resistant prostate cancer (CRPC) develops resulting in death (Fig. 3). Sign in to download full-size image Fig. 3. Schematic of prostate ...