All patients were confirmed to have adenocarcinoma by prostate needle biopsy at the time of diagnosis. The blood samples were collected once from 30 healthy donors, 60 localized PCa patients, 30 mHSPC patients with BM, 15 mCRPC patients without BM, and 80 mCRPC patients with BM. We also ...
Based on a recent review of 440 CRPC patients, CRPC-NE was seen in 11% of CRPC patients that underwent biopsy5,8,9. There is increasing evidence that CRPC-NE can directly arise from CRPC-Adeno cells through lineage plasticity (Supplementary Fig. 28), which is supported by lineage ...
One biopsy sample may have two Gleason grades, which are added together to provide a Gleason score. The higher a Gleason score, the more likely the cancer is to spread.2 Patients at high risk for the development of metastatic disease are those with Gleason score of 8 and higher, PSA ...
Metastatic prostate cancer remains a major clinical challenge and metastatic lesions are highly heterogeneous and difficult to biopsy. Liquid biopsy provides opportunities to gain insights into the underlying biology. Here, using the highly sensitive enrichment-based sequencing technology, we provide analysis...
It is possible that the pathogen might colonize the anaerobic zones of an existing prostate tumor and/or might be introduced during surgery or during previous surgical intervention, since patients who undergo radical prostatectomy usually undergo multiple biopsy procedures beforehand. Here, we wanted to...
Following the same methodology, we collected three biopsies from PCa patients during High Dose Rate Brachytherapy (HDR-BT) procedure. In two biopsy cores, the amount of the γH2AX residual foci was determined after ex-vivo irradiation with 0 and 4 Gy for comparison of inter-lesional differences...
(GO:0001525). To perform this correction, we utilized the Benjamini–Hochberg procedure with a false-discovery rate of 10% (FDR = 0.1) as described previously [26]. Heatmaps were generated by clustering genes hierarchically/agglomeratively using the 'average' method and 'euclidean' metric....
Thus, further elucidation of the specific molecules and mechanism associated with these events may lead to the development of a more effective alternative for repeat biopsy to monitor tumor progression and invasion. Keywords: focal basal cell layer disruption, prostate tumors, basement membrane ...
(Gleason 9). Orchiectomy was performed directly after biopsy sampling; thus, the tumor was androgen-dependent at the time of collection. The patient included in the study provided written informed consent (Cantonal Ethical approval KEK 06/03 and 2017-02295). PDXs tumors were maintained by ...
Carriers of this SNP allele have reduced serum total PSA and a higher free/total PSA ratio that could contribute to late biopsy decisions and delay in diagnosis. Our results provide a molecular explanation for the prominent 19q13.3 KLK locus, rs17632542 SNP, association with a spectrum of ...