Prostate cancer (PCa) is the second leading cause of cancer death in the male population1. With the massive expansion of prostate screening, PCa has become the most commonly diagnosed cancer in American men2. Thus, accurate prostate segmentation has an essential role in many medical imaging and ...
Such an approach may assist radiologists in their interpretation of MRI, thereby facilitating early detection of prostate cancer, targeting during biopsy, and local treatment. Credit author statement This statement outlines the contribution of the authors of the submitted paper. Rewa Sood: ...
Standard pathology reports may be difficult to understand for patients with prostate cancer Hannah Clarke Overall, 39% of those who received a university-formatted report and 56% of those who received a VA-formatted report were able to identify that they had prostate cancer. ...
CTCs were enriched from 7.5 ml of blood samples collected in ACD-A tubes using the Cytogen Smart Biopsy Cell Isolator (Cytogen Inc., Seoul, Korea) following the manufacturer’s protocol. In short, the double negative selection workflow involves incubation with a leukocyte and erythrocyte depletion ...
doi:10.1001/jamanetworkopen.2020.5111 Machine Learning Website Key Points Question Can deep learning systems perform hematoxylin and eosin (H&E) staining and destaining and are the virtual core biopsy samples generated by them as valid and interpretable as their real-life unstained and H&E dye–...
that ACPP is only enriched in the tumor region in section 3.3. It is enriched innon-tumorregions in section 1.2 and 2.4. (Fig.S1B). This highlights the spatially heterogeneous expression pattern of this known marker gene that would have been missed by bulk averaging of the whole biopsy. ...
It showed an enlarged prostate with irregular prostatic outlines, heterogenous signals in all sequences, a prostatic cyst and a preserved recto-prostatic plane. A systematic trans-rectal ultrasound guided biopsy of the prostate showed a Gleason grade 5 + 5 in all cores, with glandular features on...
The FDA approval letter specifies that the test's intended use is for men 50 years of age or older who have had a previous negative biopsy (and no finding of atypical small aci- nar proliferation) and are being considered for a repeat biopsy. However, several reference laboratories offer ...
Generating models that are derived from biopsy specimens and metastatic lesions from human patients is one means of mitigating this dilemma. One form of patient-derived models is xenografts (PDXs), which allow researchers to study and appreciate the tumor heterogeneity of prostatic diseases. It has ...
Therefore, the combination could be used as a diagnostic marker in patients with indications of prostate cancer, such as elevated serum PSA values and a history of negative biopsy, directing the need for a repeat biopsy [36,37]. A few years ago, a meta-analysis demonstrated that ERG ...