NON-STEROIDAL ANTI-INFLAMMATORY DRUGS: HOW DO THEY DAMAGE THE GUT? NSAIDs are widely prescribed for the treatment of musculoskeletal disorders. The gastrointestinal tract, predominantly the stomach, bears the brunt of their side-effects. The basis of this toxicity is certainly multifactorial, with a...
Infection regulates pro-resolving mediators that lower antibiotic requirements. Underlying mechanisms for how bacterial infections contribute to active resolution of acute inflammation are unknown. Here, we performed exudate leukocyte ... C Nan,G Fredman,Fredrik Backhed,... - 《Nature》 被引量: 580...
Read on to learn what prostaglandins are, how they work, and how they affect your health. What Are Prostaglandins? Prostaglandins are hormone-like substances with diverse roles in the body, principally the acute immune reaction and inflammation [1]. Unlike typical hormones, prostaglandins are not ...
Serpins illustrate how a common structure motif may be adapted to multiple functions. Other examples of plasma protein families are the albumin and lipocalin families. The albumin family includes albumin, α-fetoprotein, and afamin. The lipocalin family includes several plasma proteins such as α1-...
to elucidate how prostaglandins play their roles for such signaling at the cellular and molecular levels. Here, we briefly summarize the roles of arachidonic acid-derived prostaglandins, focusing on four prostaglandins and one thromboxane, particularly in terms of their actions on afferent nociceptors. ...
How to Cite SCHICK, H., SPANIG, J., MAHRWALD, R., BOHLE, M., REIHER, T. and PIVNITSKY, K. K. (1992), ChemInform Abstract: Prostaglandins and Prostaglandin Intermediates. Part 28. Investigation of the Diastereofacial Selectivity of the Addition of 1-Metalated (E)- and (Z)-Hept-1...
Despite the above described studies indicating the involvement of prostanoid receptors in cancer (Figure1), it still remains to be defined when and how prostanoid receptors are enlisted during tumor formation and progression, and whether prostanoid receptors can be a target of intervention for can...
It is well known that there is substantial donor-to-donor variation in how well RBCs store from the standpoint of post-transfusion RBC recovery; however, it is unclear whether the accumulation of eicosanoids varies substantially among donors. If differences exist, then it may be useful to screen...
In Flowsheet B is shown how the novel cyclopentenones (VI) embraced in this invention are prepared. ##STR10## In Flowsheet B above R1, R3, R4, R5 and Z are as hereinabove defined. As indicated in the above scheme, treatment of the hydroxycyclopentanones (IV) in which there is a tra...
Find out how to access preview-only content Chromatographia 1974, Volume 7, Issue 4, pp 200-202 Separation of prostaglandins on silica gel impregnated glass fiber paper and estimation by transmission densitometryE. J. Singh, F. P. Zuspan … show all 2 hide ...