A viscous suspension of prostaglandin E 2 was introduced endocervically to induce labor in patients with favourable induction features. The method was found to be effective and compared favourably with the conventional practices of amniotomy and intravenous oxytocin infusion or oral prostaglandin therapy...
A randomized double-blind, placebo-controlled study was undertaken to evaluate the effect of a single intracervical application of prostaglandin E2 gel on the ripening of the cervix and on the subsequent induction of labor with oxytocin in patients with low Bishop scores (≤4). Compared to contro...
This time someone tries to induce labour. In goes the prostaglandin gel. Maybe later a second dose. In some cases oxytocin follows, and the labouring woman reports pain. 'There, there, yes I know it hurrs,' says the kindly midwife, not picking up the difference in location or the type...
stimulate uterine muscle contraction—a discovery that led to the successful treatment of menstrual cramps (dysmenorrhea) with inhibitors of prostaglandin synthesis, such as ibuprofen. Prostaglandins also play a role in inducing labor in pregnant women at term, and they are given to induce therapeutic...
170 Endometriotic stromal cells produce large quantities of PGE2 that induce local estrogen biosynthesis and pelvic pain.69,119,120,171 COX2 is strikingly up-regulated in endometriotic cells compared with endometrial stromal cells; moreover, its expression is also higher in endometrium of women with ...
(2006)have recently reported that there was no labor-associated induction of PTGFS in pregnant sheep cervix which also suggested that the labor associated rise of E2may not be able to stimulate cervical PTGFS expression. Consistent with Palliser’s finding, we failed to induce the cervical PT...
The amnion fibroblasts are particularly responsive to the stimulatory effects of glucocorticoids (405), and glucocorticoids also induce expression of cPLA2 but not PGES in these cells (485). In addition, 11βHSD-1 activity has been described in these cells, and its expression can be induced ...
A single extra-amniotic injection of prostaglandin (PG) E2 or F2alpha in a highly viscous gel was administered to 230 patients to induce abortion between 9... IZ Mackenzie,MP Embrey - 《Br Med J》 被引量: 259发表: 1977年 A prospective, randomized comparison of Foley catheter insertion vers...
It compared two groups: (1) women giving birth in a hospital that uses a protocol for mechanical cervical ripening by a double-balloon catheter (DBC), and (2) women giving birth in a hospital that performed pharmacological cervical ripening by prostaglandins. The principal endpoint was the ...
FP agonists can also be used for fertility control, to manage vascular diseases such as diabetic and other forms of peripheral vascular disease, to induce labor, and as nasal decongestants. FP antagonists can be used to prevent premature labor and to prevent hyper-pigmentation of the skin. PGF...